The MB Iso-enzyme of creatine phosphokinase in myocardial infarction (author's transl)

CPK and its MB iso-enzymatic fraction were measured in 240 patients, 180 of whom suffered from myocardial infarction. MB iso-enzyme was expressed as a percentage of total CPK and a minimum figure of 4 per cent of MB isoenzyme was taken as indicative of a diagnosis of myocardial infarction. In the 18...

Full description

Saved in:
Bibliographic Details
Published inLa Nouvelle presse medicale Vol. 7; no. 3; p. 177
Main Authors Jeanmet, A, Cramer, J, Goullé, J P, Méchard, D, Lainé, G, Maitrot, B, Letac, B
Format Journal Article
LanguageFrench
Published France 21.01.1978
Subjects
Adult
Aged
Clinical Enzyme Tests
Creatine Kinase - blood
Female
Humans
Isoenzymes - blood
Male
Middle Aged
Myocardial Infarction - diagnosis
Myocardium - enzymology
Online AccessGet more information

Cover

More Information
Summary:CPK and its MB iso-enzymatic fraction were measured in 240 patients, 180 of whom suffered from myocardial infarction. MB iso-enzyme was expressed as a percentage of total CPK and a minimum figure of 4 per cent of MB isoenzyme was taken as indicative of a diagnosis of myocardial infarction. In the 180 patients with an infarction, the average MB level as a percentage of total CPK was 12.1 +/- 5.4 per cent. Five patients with a proven infarct had an MB iso-enzyme level of less than 4 per cent. Amongst the 60 patients without a myocardial infarction who were included in view of a pathological level of CPK, the average maximum level of MB was 1 +/- 2.5 per cent. Five of these 60 patients (false positives: 8.3%) had an MB iso-enzyme level of greater than 4 per cent. It is concluded that the estimation of MB iso-enzyme of CPK using a chromatographic technic is a highly valuable laboratory method for confirming or eliminating a diagnosis of myocardial infarction in the numerous clinical circumstances when such a diagnosis is difficult or even impossible on the basis of standard data.
ISSN:0301-1518