Synthesis of 2,3-diazaphenothiazine. XI. 2- and 3-arylderivatives of 10-methyl-2,3-dihydropyridazine /4,5-b/ / 1,4/ benzothiazin-1,4(10H)-dione

The synthesis of 3-phenyl-10-methyl-2,3-dihydropyridazine[4,5-b] [1,4]benzothiazin-1,4(10H)-dione (I) and the 2 phenyl siomer-(II) is described. The compounds were prepared by the reaction of 2-methylaminothiophenol with 1,2-dihydro-20phenyl-4,5-dibromopyridazin-3,6-dione in an alkaline aqueous/alco...

Full description

Saved in:
Bibliographic Details
Published inIl Farmaco; edizione scientifica Vol. 32; no. 3; p. 173
Main Authors Duro, F, Condorelli, P, Pappalardo, G
Format Journal Article
LanguageItalian
Published Italy 01.03.1977
Subjects
Cyclization
Fibrinolytic Agents - chemical synthesis
Isomerism
Methylation
Phenothiazines - chemical synthesis
Pyridazines - chemical synthesis
Thiazines - chemical synthesis
Online AccessGet more information

Cover

More Information
Summary:The synthesis of 3-phenyl-10-methyl-2,3-dihydropyridazine[4,5-b] [1,4]benzothiazin-1,4(10H)-dione (I) and the 2 phenyl siomer-(II) is described. The compounds were prepared by the reaction of 2-methylaminothiophenol with 1,2-dihydro-20phenyl-4,5-dibromopyridazin-3,6-dione in an alkaline aqueous/alcoholic medium. The structure of the two isomers was demonstrated by transformation of (I) into 3-phenyl-10-methyl-3H-pyridazino[4,5-b] [1,4]benzothiazin-4(10H)-one (IV) reported in the literature.
ISSN:0430-0920