Physiochemical properties of 7-aminoacetoxycephalosporanic acid

Potentiometric titration of the zwitter-ion of 7-aminoacetoxycephalosporanic acid (7-ACA) was performed and the constants of its ionization were estimated. The minimum solubility of the 7-ACA zwitter-ion (20 degrees C, 0.1 M NaCl) was determined and the solubility curve of 7-ACA at wide pH ranges wa...

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Bibliographic Details
Published inAntibiotiki Vol. 22; no. 12; p. 1073
Main Authors Bulycheva, M S, Nys, P S, Savitskaia, E M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.12.1977
Subjects
Cephalosporins - analysis
Cephalosporins - pharmacology
Chemical Phenomena
Chemistry, Physical
Hydrogen-Ion Concentration
Potentiometry
Solubility
Temperature
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Summary:Potentiometric titration of the zwitter-ion of 7-aminoacetoxycephalosporanic acid (7-ACA) was performed and the constants of its ionization were estimated. The minimum solubility of the 7-ACA zwitter-ion (20 degrees C, 0.1 M NaCl) was determined and the solubility curve of 7-ACA at wide pH ranges was calculated. Equilibrium of the cationic, zwitter-ionic and anionic forms of 7-ACA was estimated as dependent on pH.
ISSN:0003-5637