Model of motion sickness in dogs for assessing the effectiveness of pharmacological substances

The paper describes a model of motion sickness for dogs. The method is based on the simultaneous use of vertical and rotatory movement of the device with a continuously varying angular velocity of rotation to generate Coriolis acceleration. The exposure increases significantly the number of sick ani...

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Bibliographic Details
Published inKosmicheskaia biologiia i aviakosmicheskaia meditsina Vol. 11; no. 6; p. 50
Main Author Radkevich, L A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1977
Subjects
Animals
Antiemetics - therapeutic use
Benzamides - therapeutic use
Coriolis Force
Cyclizine - therapeutic use
Disease Models, Animal
Dogs
Drug Evaluation, Preclinical
Female
Histamine H1 Antagonists - therapeutic use
Male
Metoclopramide - therapeutic use
Motion Sickness - drug therapy
Parasympatholytics - therapeutic use
Piperidines - therapeutic use
Time Factors
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Summary:The paper describes a model of motion sickness for dogs. The method is based on the simultaneous use of vertical and rotatory movement of the device with a continuously varying angular velocity of rotation to generate Coriolis acceleration. The exposure increases significantly the number of sick animals to be used in the selection of antimotion drugs. Diphenidol, marezine, tigane, bromotigane and metachloropromide were tested. Diphenidol and to a lesser extent marezine and metachloropromide proved effective. Tigane and bromotigane were ineffective against motion sickness.
ISSN:0321-5040