Cerebral Function Monitor (CFM) and electroencephalography (EEG). Experimental study

• Published in: Annales de l'anesthesiologie francaise Vol. 20; no. 3; p. 175
• Main Authors: Laborit, G, Roujas, F, Baron, C, Rivet, P
• Format: Journal Article
• Language: French
• Published: France 1979
• Subjects: Alfaxalone Alfadolone Mixture - pharmacology; Animals; Brain - physiology; Chlorprothixene - pharmacology; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography - instrumentation; Hemodynamics; Monitoring, Physiologic - instrumentation; Pain - physiopathology; Rabbits; Reticular Formation - physiology; Sciatic Nerve - physiology
• ISSN: 0003-4061

This work is an attempt to connect the electro-encephalogram (EEG) and monitor of cerebral function (MCF) recordings during the experimental stimulation of the rabbit brain whether this is in the from of direct central stimulation, by stereotaxic location, or in the form of indirect stimulation via a peripheral nerve. These stimulations, performed under alfadione anaesthesia or under the neuroleptanalgesic sedative effect of chlorprothixine, are compared for every animal with the results of the control stimulations. The cardiovascular responses are recorded simultaneously. It has been found that, in simple narcosis induced by alfadione, there is much variation in the EEG recording and even more so in the MCF recording according to the quantity used and the block of responses to stimuli does not appear until there is deep anaesthesia. However, when chlorprothixine is used, the MCF trace is found to be very closely related to the trace of mild anaesthesia with accompanying block to all of the nociceptive stimulations. It would seem, therefore, if we accept the concept of levels of cerebral activity, that the use of the MCF could well open the way to a better understanding of the pure narcotic phenomena and of the neurovegetative response block to aggression.