The influence of isoglaucon on the hydrodynamics and haemodynamics of the eye (author's transl)

By animal experiments and clinically we could prove that isoglaucon instillation caused the decrease in IOP due to both increase in outflow and reduction of humor secretion; the IOP decrease and changes in hydrodynamics being manifested more markedly in the fellow-eye. As reoophthalmography demonstr...

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Bibliographic Details
Published inKlinische Monatsblätter für Augenheilkunde Vol. 167; no. 4; p. 542
Main Authors Bunin, A J, Jakovlev, A A, Jermakova, V N, Konde, L A
Format Journal Article
LanguageGerman
Published Germany 01.10.1975
Subjects
Animals
Aqueous Humor - drug effects
Blood Pressure - drug effects
Clonidine - administration & dosage
Clonidine - pharmacology
Glaucoma - drug therapy
Hemodynamics - drug effects
Humans
Hydrogen-Ion Concentration
Intraocular Pressure - drug effects
Ophthalmic Artery - drug effects
Ophthalmic Solutions - pharmacology
Rabbits
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Summary:By animal experiments and clinically we could prove that isoglaucon instillation caused the decrease in IOP due to both increase in outflow and reduction of humor secretion; the IOP decrease and changes in hydrodynamics being manifested more markedly in the fellow-eye. As reoophthalmography demonstrated "Isoglaucon" produced lumen narrowing in the anterior portion of the uveal tract. "Isoglaucon" was prescribed to 20 patients having open-angle-glaucoma, Two hours after instillation the 23 decreased in 26 eyes (of 28) by 9.3 +/- 1.0 mm Hg. When prescribed regularly "Isoglaucon" raised the outflow facility coefficient from 0.10 +/- 0.01 to 0.20 +/-0.02. The secretion decreased from 2.0 +/- 0.2 to 0.9 +/- 0.15. Thus, IOP decrease after "Isoglaucon" is accounted for by both improved outflow and reduction of aqueous humor secretion. The "isoglucon" instillation produced a rather moderate decrease in the total arterial pressure, though no expected parallelism in arterial and intraocular pressure was marked.
ISSN:0023-2165