Another hijack! Some enteroviruses co‐opt the c10orf76/PI4KB complex for their own good

Enteroviruses, members of the Picornaviridae family, are non‐enveloped and single‐stranded RNA viruses responsible for several human diseases. During infection, these viruses build membrane‐bound organelles, called replication organelles (ROs), where new virions are assembled. ROs are highly enriche...

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Bibliographic Details
Published inEMBO reports Vol. 21; no. 2; pp. e49876 - n/a
Main Authors Voilquin, Laetitia, Di Mattia, Thomas, Alpy, Fabien
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 05.02.2020
Blackwell Publishing Ltd
John Wiley and Sons Inc
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Summary:Enteroviruses, members of the Picornaviridae family, are non‐enveloped and single‐stranded RNA viruses responsible for several human diseases. During infection, these viruses build membrane‐bound organelles, called replication organelles (ROs), where new virions are assembled. ROs are highly enriched in phosphatidylinositol 4‐phosphate (PI4P) produced by the host lipid kinase PI4KB. In this issue of EMBO Reports , McPhail et al [1] characterize a complex, formed by PI4KB and the c10orf76 protein, which is involved in PI4P production. They show that this machinery is hijacked by specific enteroviruses such as coxsackievirus A10 for their replication. Graphical Abstract A new study characterizes a complex involved in PI4P production and shows that this machinery is hijacked by specific enteroviruses such as Coxsackievirus A10 for their replication.
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These authors contributed equally to this work
See also: https://doi.org/10.15252/embr.201948441 (February 2020)
ISSN:1469-221X
1469-3178
1469-3178
DOI:10.15252/embr.201949876