A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX11 helicase

How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G‐quadruplex binding domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures. Gra...

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Bibliographic Details
Published inThe EMBO journal Vol. 39; no. 18; pp. e106305 - n/a
Main Author Freudenreich, Catherine H
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 15.09.2020
Blackwell Publishing Ltd
John Wiley and Sons Inc
Subjects
Deoxyribonucleic acid
DNA
DNA - genetics
DNA biosynthesis
DNA helicase
DNA Helicases - genetics
DNA Helicases - metabolism
DNA Replication
EMBO13
EMBO40
G-Quadruplexes
News & Views
Timeless protein
Unwinding
Views
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Summary:How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G‐quadruplex binding domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures. Graphical Abstract New work identifies a G‐quadruplex binding domain in human Timeless that facilitates DDX11 recruitment and replication through DNA secondary structures.
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See also: LK Lerner et al (September 2020)
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2020106305