Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment
Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also r...
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Published in | European journal of clinical investigation Vol. 48; no. S2; pp. e12939 - n/a |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.11.2018
John Wiley and Sons Inc |
Subjects | |
Online Access | Get full text |
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Abstract | Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment. |
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AbstractList | Rac‐
GTP
ases and their Rac‐
GEF
activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐
GTP
ases and Rac‐
GEF
s in neutrophil adhesion, migration and recruitment. Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment. |
Author | Pantarelli, Chiara Welch, Heidi C. E. |
AuthorAffiliation | 1 Signalling Programme Babraham Institute Cambridge UK |
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Copyright | The Authors. published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. Copyright © 2018 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd |
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Keywords | Rho-GTPases guanine-nucleotide exchange factors Vav P-Rex1 neutrophils small G proteins |
Language | English |
License | Attribution The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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Snippet | Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the... Rac-GTPases and their Rac-GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the... Rac‐ GTP ases and their Rac‐ GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the... |
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SubjectTerms | Adhesion Cell activation Cell Adhesion - physiology Cell Movement - physiology Cytoskeleton Guanine Nucleotide Exchange Factors - physiology guanine‐nucleotide exchange factors Humans Leukocyte migration Leukocytes (neutrophilic) Neutrophil Infiltration - physiology Neutrophils Neutrophils - enzymology Neutrophils - physiology Neutrophils. Guest Editor: Dirk Roos Proteins Proto-Oncogene Proteins c-vav - physiology P‐Rex1 rac GTP-Binding Proteins - physiology rac1 GTP-Binding Protein - physiology Recruitment Review Rho Guanine Nucleotide Exchange Factors - physiology Rho‐GTPases Signal Transduction - physiology small G proteins T-Lymphoma Invasion and Metastasis-inducing Protein 1 - physiology Vav |
Title | Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment |
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