Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment
Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also r...
Saved in:
| Published in | European journal of clinical investigation Vol. 48; no. S2; pp. e12939 - n/a |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.11.2018
John Wiley and Sons Inc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment. |
|---|---|
| AbstractList | Rac‐
GTP
ases and their Rac‐
GEF
activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐
GTP
ases and Rac‐
GEF
s in neutrophil adhesion, migration and recruitment. Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment. |
| Author | Pantarelli, Chiara Welch, Heidi C. E. |
| AuthorAffiliation | 1 Signalling Programme Babraham Institute Cambridge UK |
| AuthorAffiliation_xml | – name: 1 Signalling Programme Babraham Institute Cambridge UK |
| Author_xml | – sequence: 1 givenname: Chiara surname: Pantarelli fullname: Pantarelli, Chiara organization: Babraham Institute – sequence: 2 givenname: Heidi C. E. orcidid: 0000-0001-7865-7000 surname: Welch fullname: Welch, Heidi C. E. email: heidi.welch@babraham.ac.uk organization: Babraham Institute |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29682742$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkUtOwzAQhi0EgvJYcAEUiQ0LUvzIw94goaotlRAgBGvLcSetUeIUOwGx4wickZNgSqkAb2bk-fx7Zv5dtGkbCwgdEtwn4ZyBNn1CBRMbqEdYlsaUZXQT9TAmSUxFTnfQrvePGGNOGN1GO1RknOYJ7aHrO6U_3t7H97fKg4-UnUarm-HIR8ZGFrrWNYu5qSI1nYM3jT2NajNzqg3p8oED7TrT1mDbfbRVqsrDwSruoYfR8H5wGV_djCeDi6t4wTIhYkZ5qkGAoElRFiVWIoEiV5rzkgPRggMnuciBQQaCpEJDoVKWcC3KdKpVyfbQ-bfuoitqmOrwtVOVXDhTK_cqG2Xk34o1czlrnmXGKBG5CAInKwHXPHXgW1kbr6GqlIWm85LisKMkYUkW0ON_6GPTORvGk5QwTDOK0zRQR787Wrfys-oAnH0DL6aC13WdYPnloQweyqWHcjiYLBP2Cfl_km0 |
| ContentType | Journal Article |
| Copyright | The Authors. published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. Copyright © 2018 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd |
| Copyright_xml | – notice: The Authors. published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation – notice: The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. – notice: Copyright © 2018 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd |
| DBID | 24P WIN CGR CUY CVF ECM EIF NPM 7QO 7U7 7U9 8FD C1K FR3 H94 P64 7X8 5PM |
| DOI | 10.1111/eci.12939 |
| DatabaseName | Wiley-Blackwell Open Access Collection Wiley Online Library Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Biotechnology Research Abstracts Toxicology Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Biotechnology Research Abstracts Technology Research Database Toxicology Abstracts AIDS and Cancer Research Abstracts Engineering Research Database Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | Virology and AIDS Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley-Blackwell Open Access Collection url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | PANTARELLI and WELCH |
| EISSN | 1365-2362 |
| EndPage | n/a |
| ExternalDocumentID | 29682742 ECI12939 |
| Genre | reviewArticle Journal Article Review |
| GrantInformation_xml | – fundername: Biotechnology and Biological Sciences Research Council funderid: BB/P013384/1 – fundername: Biotechnology and Biological Sciences Research Council grantid: BB/P013384/1 – fundername: Biotechnology and Biological Sciences Research Council grantid: BBS/E/B/000C0411 |
| GroupedDBID | --- -~X .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 24P 29G 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHEFC AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 DUUFO EAD EAP EAS EBB EBC EBD EBS EBX EJD EMB EMK EMOBN EPT ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK0 MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI Q.N Q11 QB0 Q~Q R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 W8V W99 WBKPD WH7 WHWMO WIH WIJ WIK WIN WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 YFH ZGI ZXP ZZTAW ~IA ~WT CGR CUY CVF ECM EIF NPM 7QO 7U7 7U9 8FD C1K FR3 H94 P64 7X8 5PM |
| ID | FETCH-LOGICAL-p3699-3285ce9e924bfbf0a94eb7ac88f8e1c98e81797e3e6e9159ceba5348c9f5dcaf3 |
| IEDL.DBID | DR2 |
| ISSN | 0014-2972 |
| IngestDate | Tue Sep 17 21:05:32 EDT 2024 Thu Aug 15 23:40:53 EDT 2024 Thu Oct 10 22:07:17 EDT 2024 Sat Sep 28 08:25:42 EDT 2024 Sat Aug 24 00:55:16 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | S2 |
| Keywords | Rho-GTPases guanine-nucleotide exchange factors Vav P-Rex1 neutrophils small G proteins |
| Language | English |
| License | Attribution The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p3699-3285ce9e924bfbf0a94eb7ac88f8e1c98e81797e3e6e9159ceba5348c9f5dcaf3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 The legal statement for this article was changed on 19 December 2018 after original online publication. |
| ORCID | 0000-0001-7865-7000 |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://onlinelibrary.wiley.com/doi/abs/10.1111%2Feci.12939 |
| PMID | 29682742 |
| PQID | 2130262055 |
| PQPubID | 36545 |
| PageCount | 10 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6321979 proquest_miscellaneous_2029644346 proquest_journals_2130262055 pubmed_primary_29682742 wiley_primary_10_1111_eci_12939_ECI12939 |
| PublicationCentury | 2000 |
| PublicationDate | November 2018 |
| PublicationDateYYYYMMDD | 2018-11-01 |
| PublicationDate_xml | – month: 11 year: 2018 text: November 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: Oxford – name: Hoboken |
| PublicationTitle | European journal of clinical investigation |
| PublicationTitleAlternate | Eur J Clin Invest |
| PublicationYear | 2018 |
| Publisher | Blackwell Publishing Ltd John Wiley and Sons Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: John Wiley and Sons Inc |
| References | 2004; 166 2015; 36 2017; 8 2010; 18 2004; 23 2008; 9 2006; 174 2014; 26 2006; 176 2013; 121 2017; 198 2003; 114 2007; 109 2006; 177 2011; 127 2014; 127 2014; 5 2013; 13 2015; 135 2013; 319 2018; 217 2002; 100 2000; 96 2000; 97 2014; 15 2011; 21 1999; 10 2002; 108 2014; 6 2016; 197 2009; 324 2014; 123 2015; 6 2004; 104 2007; 282 2009; 182 2015; 125 2005; 235 2017; 24 2005; 118 2009; 297 2006; 7 2013; 93 2015; 1851 2003; 171 2003; 170 2014; 2014 2014; 193 2016; 11 2008; 180 2006; 108 2007; 117 2002; 169 2017; 10 2013; 210 2005; 52 2014; 36 2018 2005; 6 2007; 81 2016; 60 2009; 4 2003; 302 2005; 15 2016; 291 2016; 23 2011; 186 |
| References_xml | – volume: 10 start-page: 1323 year: 2017 end-page: 1332 article-title: Overexpression of microRNA‐722 fine‐tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish publication-title: Dis Model Mech – volume: 127 start-page: 535 year: 2011 end-page: 538 article-title: Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T‐cell lymphopenia publication-title: J Allergy Clin Immunol – volume: 11 start-page: e0154491 year: 2016 article-title: A worldwide competition to compare the speed and chemotactic accuracy of neutrophil‐like cells publication-title: PLoS ONE – volume: 319 start-page: 2375 year: 2013 end-page: 2383 article-title: Hematopoietic‐specific Rho GTPases Rac2 and RhoH and human blood disorders publication-title: Exp Cell Res – volume: 282 start-page: 29967 year: 2007 end-page: 29976 article-title: Membrane translocation of P‐Rex1 is mediated by G protein βγ subunits and phosphoinositide 3‐kinase publication-title: J Biol Chem – volume: 109 start-page: 1257 year: 2007 end-page: 1264 article-title: Rho GTPase Rac1 is critical for neutrophil migration into the lung publication-title: Blood – volume: 21 start-page: 735 year: 2011 end-page: 745 article-title: Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue publication-title: Dev Cell – volume: 93 start-page: 269 year: 2013 end-page: 309 article-title: Regulation of small GTPases by GEFs, GAPs, and GDIs publication-title: Physiol Rev – volume: 15 start-page: 602 year: 2014 end-page: 611 article-title: Neutrophils at work publication-title: Nat Immunol – volume: 193 start-page: 5660 year: 2014 end-page: 5667 article-title: DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation publication-title: J Immunol – volume: 100 start-page: 3853 year: 2002 end-page: 3860 article-title: Leukocyte extravasation: chemokine transport and presentation by the endothelium publication-title: Blood – volume: 6 start-page: 167 year: 2005 end-page: 180 article-title: GEF means go: turning on Rho GTPases with guanine nucleotide‐exchange factors publication-title: Nat Rev Mol Cell Biol – volume: 5 start-page: 9 year: 2014 article-title: Vav family exchange factors: an integrated regulatory and functional view publication-title: Small GTPases – volume: 170 start-page: 5652 year: 2003 end-page: 5657 article-title: Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions publication-title: J Immunol – start-page: 4142 year: 2018 end-page: 4154 – volume: 24 start-page: 23 year: 2017 end-page: 31 article-title: Platelets in neutrophil recruitment to sites of inflammation publication-title: Curr Opin Hematol – volume: 235 start-page: 92 year: 2005 end-page: 97 article-title: The role of Rac1 and Rac2 in bacterial killing publication-title: Cell Immunol – volume: 324 start-page: 384 year: 2009 end-page: 387 article-title: Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis publication-title: Science – volume: 108 start-page: 809 year: 2002 end-page: 821 article-title: P‐Rex1, a PtdIns(3,4,5)P ‐ and Gβγ‐regulated guanine‐nucleotide exchange factor for Rac publication-title: Cell – volume: 104 start-page: 3758 year: 2004 end-page: 3765 article-title: Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass publication-title: Blood – volume: 15 start-page: 1867 year: 2005 end-page: 1873 article-title: P‐Rex1 regulates neutrophil function publication-title: Curr Biol – volume: 186 start-page: 1467 year: 2011 end-page: 1476 article-title: P‐Rex1 and Vav1 cooperate in the regulation of fMLF‐dependent neutrophil responses publication-title: J Immunol – volume: 177 start-page: 6388 year: 2006 end-page: 6397 article-title: Vav proteins in neutrophils are required for Fc{gamma}R‐mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox) publication-title: J Immunol – volume: 6 start-page: 1153 year: 2014 end-page: 1164 article-title: The Rac‐FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues publication-title: Cell Rep – volume: 13 start-page: 159 year: 2013 end-page: 175 article-title: Neutrophil recruitment and function in health and inflammation publication-title: Nat Rev Immunol – volume: 26 start-page: 483 year: 2014 end-page: 491 article-title: The guanine nucleotide exchange factor Tiam1: a Janus‐faced molecule in cellular signaling publication-title: Cell Signal – volume: 174 start-page: 647 year: 2006 end-page: 652 article-title: DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis publication-title: J Cell Biol – volume: 117 start-page: 3445 year: 2007 end-page: 3452 article-title: Neutrophil‐mediated oxidative burst and host defense are controlled by a Vav‐PLCgamma2 signaling axis in mice publication-title: J Clin Invest – volume: 118 start-page: 843 year: 2005 end-page: 846 article-title: The Ras superfamily at a glance publication-title: J Cell Sci – volume: 81 start-page: 1127 year: 2007 end-page: 1136 article-title: Signaling requirements for translocation of P‐Rex1, a key Rac2 exchange factor involved in chemoattractant‐stimulated human neutrophil function publication-title: J Leukoc Biol – volume: 15 start-page: 1874 year: 2005 end-page: 1879 article-title: P‐Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils publication-title: Curr Biol – volume: 125 start-page: 1146 year: 2015 end-page: 1158 article-title: P‐Rex and Vav Rac‐GEFs in platelets control leukocyte recruitment to sites of inflammation publication-title: Blood – volume: 135 start-page: 1380 year: 2015 end-page: 1384 article-title: RAC2 loss‐of‐function mutation in 2 siblings with characteristics of common variable immunodeficiency publication-title: J Allergy Clin Immunol – volume: 23 start-page: 3492 year: 2004 end-page: 3504 article-title: Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool‐2/alpha‐Pix publication-title: EMBO J – volume: 169 start-page: 5043 year: 2002 end-page: 5051 article-title: Chemoattractant‐stimulated Rac activation in wild‐type and Rac2‐deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions publication-title: J Immunol – volume: 60 start-page: 36 year: 2016 end-page: 45 article-title: Localizing the lipid products of PI3Kgamma in neutrophils publication-title: Adv Biol Regul – volume: 302 start-page: 445 year: 2003 end-page: 449 article-title: Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases publication-title: Science – volume: 8 start-page: 1 year: 2017 end-page: 9 article-title: Cross‐talk between Rho GTPases and PI3K in the neutrophil publication-title: Small GTPases – volume: 97 start-page: 4654 year: 2000 end-page: 4659 article-title: Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation publication-title: Proc Natl Acad Sci U S A – volume: 182 start-page: 6870 year: 2009 end-page: 6878 article-title: Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature publication-title: J Immunol – volume: 7 start-page: 724 year: 2006 end-page: 731 article-title: Neutrophil direction sensing and superoxide production linked by the GTPase‐activating protein GIT2 publication-title: Nat Immunol – volume: 23 start-page: 44 year: 2016 end-page: 54 article-title: Small GTPases and their guanine‐nucleotide exchange factors and GTPase‐activating proteins in neutrophil recruitment publication-title: Curr Opin Hematol – volume: 180 start-page: 6279 year: 2008 end-page: 6287 article-title: Requirement for Vav proteins in post‐recruitment neutrophil cytotoxicity in IgG but not complement C3‐dependent injury publication-title: J Immunol – volume: 52 start-page: 1297 year: 2005 end-page: 1304 article-title: Innate immunity and arthritis: neutrophil Rac and toll‐like receptor 4 expression define outcomes in infection‐triggered arthritis publication-title: Arthritis Rheum – volume: 10 start-page: 183 year: 1999 end-page: 196 article-title: Deficiency of the hematopoietic cell‐specific rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense publication-title: Immunity – volume: 6 start-page: 1 year: 2015 end-page: 11 article-title: Regulation and function of P‐Rex family Rac‐GEFs publication-title: Small GTPases – volume: 36 start-page: 103 year: 2015 end-page: 112 article-title: Rho GTPase signalling in cell migration publication-title: Curr Opin Cell Biol – volume: 198 start-page: 1887 year: 2017 end-page: 1899 article-title: Mechanisms of impaired neutrophil migration by microRNAs in myelodysplastic syndromes publication-title: J Immunol – volume: 4 start-page: e4652 year: 2009 article-title: ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in vivo publication-title: PLoS ONE – volume: 36 start-page: 227 year: 2014 end-page: 251 article-title: The multiple faces of leukocyte interstitial migration publication-title: Semin Immunopathol – volume: 217 start-page: 447 year: 2018 end-page: 457 article-title: Rho GTPase signaling complexes in cell migration and invasion publication-title: J Cell Biol – volume: 176 start-page: 5314 year: 2006 end-page: 5320 article-title: RhoG regulates the neutrophil NADPH oxidase publication-title: J Immunol – volume: 96 start-page: 1646 year: 2000 end-page: 1654 article-title: Dominant negative mutation of the hematopoietic‐specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency publication-title: Blood – volume: 18 start-page: 226 year: 2010 end-page: 236 article-title: Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish publication-title: Dev Cell – volume: 123 start-page: 2084 year: 2014 end-page: 2093 article-title: ATF3 is a novel regulator of mouse neutrophil migration publication-title: Blood – volume: 197 start-page: 4780 year: 2016 end-page: 4790 article-title: Rac2 functions in both neutrophils and macrophages to mediate motility and host defense in larval zebrafish publication-title: J Immunol – volume: 1851 start-page: 882 year: 2015 end-page: 897 article-title: PI3K signalling in inflammation publication-title: Biochim Biophys Acta – volume: 2014 start-page: 303782 year: 2014 article-title: Congenital defects in neutrophil dynamics publication-title: J Immunol Res – volume: 9 start-page: 690 year: 2008 end-page: 701 article-title: Mammalian Rho GTPases: new insights into their functions from in vivo studies publication-title: Nat Rev Mol Cell Biol – volume: 291 start-page: 6359 year: 2016 end-page: 6375 article-title: Norbin stimulates the catalytic activity and plasma membrane localization of the guanine‐nucleotide exchange factor P‐Rex1 publication-title: J Biol Chem – volume: 210 start-page: 1283 year: 2013 end-page: 1299 article-title: Diverse novel functions of neutrophils in immunity, inflammation, and beyond publication-title: J Exp Med – volume: 171 start-page: 4425 year: 2003 end-page: 4430 article-title: The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N‐formyl‐methionyl‐leucyl‐phenylalanine‐activated neutrophil functions publication-title: J Immunol – volume: 114 start-page: 215 year: 2003 end-page: 227 article-title: Directional sensing requires Gβγ‐mediated PAK1 and PIXα‐dependent activation of Cdc42 publication-title: Cell – volume: 127 start-page: 2589 year: 2014 end-page: 2600 article-title: P‐Rex1 directly activates RhoG to regulate GPCR‐driven Rac signalling and actin polarity in neutrophils publication-title: J Cell Sci – volume: 297 start-page: L1091 year: 2009 end-page: L1102 article-title: Regulation of inflammation by Rac2 in immune complex‐mediated acute lung injury publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 108 start-page: 2814 year: 2006 end-page: 2820 article-title: Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis publication-title: Blood – volume: 166 start-page: 273 year: 2004 end-page: 282 article-title: Vav GEFs are required for β2 integrin‐dependent functions of neutrophils publication-title: J Cell Biol – volume: 121 start-page: 2301 year: 2013 end-page: 2310 article-title: Integrin activation by P‐Rex1 is required for selectin‐mediated slow leukocyte rolling and intravascular crawling publication-title: Blood |
| SSID | ssj0008132 |
| Score | 2.437904 |
| SecondaryResourceType | review_article |
| Snippet | Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the... Rac-GTPases and their Rac-GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the... Rac‐ GTP ases and their Rac‐ GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the... |
| SourceID | pubmedcentral proquest pubmed wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | e12939 |
| SubjectTerms | Adhesion Cell activation Cell Adhesion - physiology Cell Movement - physiology Cytoskeleton Guanine Nucleotide Exchange Factors - physiology guanine‐nucleotide exchange factors Humans Leukocyte migration Leukocytes (neutrophilic) Neutrophil Infiltration - physiology Neutrophils Neutrophils - enzymology Neutrophils - physiology Neutrophils. Guest Editor: Dirk Roos Proteins Proto-Oncogene Proteins c-vav - physiology P‐Rex1 rac GTP-Binding Proteins - physiology rac1 GTP-Binding Protein - physiology Recruitment Review Rho Guanine Nucleotide Exchange Factors - physiology Rho‐GTPases Signal Transduction - physiology small G proteins T-Lymphoma Invasion and Metastasis-inducing Protein 1 - physiology Vav |
| Title | Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Feci.12939 https://www.ncbi.nlm.nih.gov/pubmed/29682742 https://www.proquest.com/docview/2130262055 https://search.proquest.com/docview/2029644346 https://pubmed.ncbi.nlm.nih.gov/PMC6321979 |
| Volume | 48 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VHhAX3o9AqYLEgQNZJfEjtjihapeC1KqqWqkHpMh2Jt0IyK52NxdO_AR-I7-EsZMNLXBA3KLYIyUaf57PnvFngJd5akVmnEwqkbKEc5QEKVq1yroQ2pKRDlJKR8fy8Jx_uBAXO_Bmexam14cYN9w8MsJ87QFu7PoKyNE1Ex-s_OE9L6TnCdHpL-kolbFeKTzjSa6LfFAV8lU8o-XfWOWfxZFXSWuIOrM78HH7vX2xyadJt7ET9_U3Kcf__KG7cHtgo_Hbfvjcgx1s78PNoyHf_gCOT4378e37u7MTCnbr2LRVPLyZztZx08YtdpvVYjlvPsemmqPfensdf2ku-3EVDGhKXXVNKGZ_COez6dnBYTLcwJAsmdQ6YbkSDjXSIs3Wtk6N5mgL45SqFWZOK1QE6AIZStREjBxaIxhXTteicqZmj2C3XbT4BGJtuJciZIL4Cq-RQkTKsWIys6kymJoI9ra-KAcYrcvcp1VlngoRwYuxmQDgsxqmxUVHfVKfOeaMywge964rl71SR0ktyueiIyiuOXXs4MW1r7e0zTyIbEtGc3mhI3gVfDZabBdN5K0yeKucHrwPD0__veszuEXES_VnGvdgd7Pq8DmRm43dhxs5P9kPY_knuKz4vA |
| link.rule.ids | 230,315,786,790,891,1382,11589,27955,27956,46085,46327,46509,46751 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwEB6VVoJeKsqrKaUNEgcOBCXxI7bEBVW7bKG7qtBW6i1ynAkbCbKrfdz7E_ob-SWMnWzUCg7cothzmZe_8difAd6lcSESY2VUiphFnKOkkKKqVVaZ0AUJaU-lNJ7I0TX_eiNuduDT9i5Myw_Rb7i5yPD52gW425C-F-Vo649utdKPYI87IjjH68yv-jysEtZyhSc8SnWWdrxC7hxPL_ovXPn38cj7sNWvO8OncNABxvBza-FD2MHmGTwedy3x5zD5buzv27sv0ytaj1ahacqw-zMYrsK6CRvcrJfzxaz-GZpyhm537EP4q_7Rmt4LUNZbbmp_3vwFXA8H0_NR1D2SEC2Y1DpiqRIWNVIdVVRFFRvNsciMVapSmFitUFHMZchQoibsYrEwgnFldSVKayr2EnabeYNHEGrDHVsgEwQpeIWUxWOOJZNJESuDsQngZKusvPP0VZ66zqdMYyECeNsPk4-6xoNpcL6hObFr7nLGZQCvWt3mi5ZMI6cR5drFAWQPtN5PcPzXD0eaeuZ5sCWjdJvpAN57-_QS27qGrJx7K-eD8wv_cfz_U8_gyWg6vswvLybfXsM-4STVXkE8gd31coNvCIusi1Pvcn8AY3nbVw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwEB6VVqq4VKUUSCklSBx6ICiJH7HFCbW79EFXK9RKvUWOM2EjtdnVPu78hP5GfgljJxu1ggO3KPZc5uVvPPZngI9pXIjEWBmVImYR5ygppKhqlVUmdEFC2lMpXY3k2Q2_uBW3G_BlfRem5YfoN9xcZPh87QJ8VlaPghxt_dktVvoZbHFJyMHROvNxn4ZVwlqq8IRHqc7SjlbIHePpRf8FK_8-HfkYtfplZ7gLOx1eDL-2Bn4BG9jswfZV1xF_CaMfxv7-9fDtekzL0SI0TRl2fwbDRVg3YYOr5Xw6m9R3oSkn6DbHPoX39c_W8l6Akt58Vfvj5vtwMxxcn5xF3RsJ0YxJrSOWKmFRI5VRRVVUsdEci8xYpSqFidUKFYVchgwlaoIuFgsjGFdWV6K0pmKvYLOZNvgGQm24IwtkghAFr5CSeMyxZDIpYmUwNgEcrpWVd46-yFPX-JRpLEQAH_phclHXdzANTlc0J3a9Xc64DOB1q9t81nJp5DSiXLc4gOyJ1vsJjv766UhTTzwNtmSUbTMdwLG3Ty-xLmvIyrm3cj44OfcfB_8_9T1sj0-H-ffz0eVbeE4oSbUXEA9hczlf4TtCIsviyHvcHymH2oA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rac%E2%80%90GTPases+and+Rac%E2%80%90GEFs+in+neutrophil+adhesion%2C+migration+and+recruitment&rft.jtitle=European+journal+of+clinical+investigation&rft.au=Pantarelli%2C+Chiara&rft.au=Welch%2C+Heidi+C+E&rft.date=2018-11-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0014-2972&rft.eissn=1365-2362&rft.volume=48&rft.issue=S2&rft_id=info:doi/10.1111%2Feci.12939&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0014-2972&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0014-2972&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0014-2972&client=summon |