Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment

• Published in: European journal of clinical investigation Vol. 48; no. S2; pp. e12939 - n/a
• Main Authors: Pantarelli, Chiara, Welch, Heidi C. E.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2018; John Wiley and Sons Inc
• Subjects: Adhesion; Cell activation; Cell Adhesion - physiology; Cell Movement - physiology; Cytoskeleton; Guanine Nucleotide Exchange Factors - physiology; guanine‐nucleotide exchange factors; Humans; Leukocyte migration; Leukocytes (neutrophilic); Neutrophil Infiltration - physiology; Neutrophils; Neutrophils - enzymology; Neutrophils - physiology; Neutrophils. Guest Editor: Dirk Roos; Proteins; Proto-Oncogene Proteins c-vav - physiology; P‐Rex1; rac GTP-Binding Proteins - physiology; rac1 GTP-Binding Protein - physiology; Recruitment; Review; Rho Guanine Nucleotide Exchange Factors - physiology; Rho‐GTPases; Signal Transduction - physiology; small G proteins; T-Lymphoma Invasion and Metastasis-inducing Protein 1 - physiology; Vav; Rho-GTPases; guanine-nucleotide exchange factors; Vav; P-Rex1; neutrophils; small G proteins
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1111/eci.12939

Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment.