Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment
Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also r...
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Published in | European journal of clinical investigation Vol. 48; no. S2; pp. e12939 - n/a |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.11.2018
John Wiley and Sons Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 The legal statement for this article was changed on 19 December 2018 after original online publication. |
ISSN: | 0014-2972 1365-2362 |
DOI: | 10.1111/eci.12939 |