microRNA and Chronic Lymphocytic Leukemia

Expression profiling of microRNAs identified important differences in microRNA expression between CLL samples and normal CD5+ B-cells. Researchers have first discussed the dual role of miRNAs working as tumor suppressors (inhibiting malignant potential) or as oncogenes (activating malignant potentia...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 889; p. 23
Main Authors Giza, Dana Elena, Calin, George A
Format Journal Article
LanguageEnglish
Published United States 2015
Subjects
Animals
Biomarkers, Tumor - genetics
Cell Cycle - genetics
Cell Cycle Proteins - genetics
Gene Expression Profiling
Gene Expression Regulation, Leukemic
Genetic Predisposition to Disease - genetics
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
MicroRNAs - genetics
Models, Genetic
ZAP-70
CLL
miRNAs
ATM mutation
IGHV
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Summary:Expression profiling of microRNAs identified important differences in microRNA expression between CLL samples and normal CD5+ B-cells. Researchers have first discussed the dual role of miRNAs working as tumor suppressors (inhibiting malignant potential) or as oncogenes (activating malignant potential) in CLL pathogenesis. Understanding the roles of miRNAs in leukemic cells brings information on a new layer of gene regulation and also provides new markers for improved diagnosis and prognosis, as well as novel therapeutic options for CLL patients. Herein we will focus on the roles of miRNAs in CLL, highlighting what is already known about their function, proposing a novel model of CLL predisposition and progression, and describing the challenges for the near future.
ISSN:0065-2598
DOI:10.1007/978-3-319-23730-5_2