Attention deficit hyperactivity disorder and autism spectrum disorder in children born to mothers with thyroid dysfunction: a Danish nationwide cohort study

• Published in: BJOG : an international journal of obstetrics and gynaecology Vol. 121; no. 11; pp. 1365 - 1374
• Main Authors: Andersen, SL, Laurberg, P, Wu, CS, Olsen, J
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.10.2014
• Subjects: Adult; Attention Deficit Disorder with Hyperactivity - epidemiology; Attention Deficit Disorder with Hyperactivity - etiology; Attention Deficit Disorder with Hyperactivity - metabolism; Attention Deficit Hyperactivity Disorder; Autism; autism spectrum disorder; Child Development Disorders, Pervasive - epidemiology; Child Development Disorders, Pervasive - etiology; Child Development Disorders, Pervasive - metabolism; Child of Impaired Parents; Child, Preschool; Children & youth; Cohort Studies; Denmark - epidemiology; Female; Follow-Up Studies; Humans; hyperthyroidism; Hyperthyroidism - complications; Hyperthyroidism - epidemiology; Hyperthyroidism - metabolism; hypothyroidism; Hypothyroidism - complications; Hypothyroidism - epidemiology; Hypothyroidism - metabolism; Incidence; Infant; Infant, Newborn; Male; Mothers; Pregnancy; Prenatal Exposure Delayed Effects; Proportional Hazards Models; Risk Factors; Thyroid diseases; Time Factors; Denmark; hyperthyroidism; autism spectrum disorder; hypothyroidism; Attention deficit hyperactivity disorder; pregnancy
• ISSN: 1470-0328; 1471-0528
• DOI: 10.1111/1471-0528.12681

Objective To examine the association between maternal hyper‐ and hypothyroidism and the risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in the child. Design A population‐based cohort study. Setting Singletons liveborn in Denmark between 1991 and 2004. Population A total of 857 014 singletons alive and living in Denmark at the age of 3 years. Methods Information on the diagnosis and/or treatment of maternal thyroid disease and the neurodevelopmental disorders ADHD and ASD in the child was obtained from Danish nationwide registers. The Cox proportional hazards model was used to estimate the hazard ratio (HR) with 95% confidence interval (95% CI) for risk of ADHD and ASD in children born to mothers with thyroid dysfunction, adjusting for potential confounding factors. Main outcome measures ADHD and ASD in the child. Results Altogether, 30 295 singletons (3.5%) were born to mothers with thyroid dysfunction. Maternal hyperthyroidism diagnosed and treated for the first time after the birth of the child increased the risk of ADHD in the child (adjusted HR 1.23; 95% CI 1.05–1.44), whereas hypothyroidism increased the risk of ASD (adjusted HR 1.34; 95% CI 1.14–1.59). No significant association was seen for maternal diagnosis and treatment prior to the birth of the child. Conclusions Children born to mothers diagnosed and treated for the first time for thyroid dysfunction after their birth may have been exposed to abnormal levels of maternal thyroid hormone already present during the pregnancy, and this untreated condition could increase the risk of specific neurodevelopmental disorders in the child.