Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization
Nanopatterned arrays of biomolecules are a powerful tool to address fundamental issues in many areas of biology. DNA nanoarrays, in particular, are of interest in the study of DNA-protein interactions and for biodiagnostic investigations. In this context, achieving a highly specific nanoscale assemb...
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Published in | Methods in molecular biology (Clifton, N.J.) Vol. 749; p. 169 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.01.2011
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Subjects | |
Online Access | Get more information |
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Summary: | Nanopatterned arrays of biomolecules are a powerful tool to address fundamental issues in many areas of biology. DNA nanoarrays, in particular, are of interest in the study of DNA-protein interactions and for biodiagnostic investigations. In this context, achieving a highly specific nanoscale assembly of oligonucleotides at surfaces is critical. In this chapter, we describe a method to control the immobilization of DNA on nanopatterned surfaces; the nanofabrication and the bio-functionalization involved in the process will be discussed. |
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ISSN: | 1940-6029 |
DOI: | 10.1007/978-1-61779-142-0_12 |