Association between serum soluble corin and obesity in Chinese adults: A cross‐sectional study

Objective Corin has been suggested to be associated with obesity by cell‐ and animal‐based studies. However, the association has not yet been studied in populations. Here, the aim was to explore the association in a general population of China. Methods This was a cross‐sectional study. Data on demog...

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Published inObesity (Silver Spring, Md.) Vol. 23; no. 4; pp. 856 - 861
Main Authors Peng, Hao, Zhang, Qiu, Shen, Hengshan, Liu, Yan, Chao, Xiangqin, Tian, Honggang, Cai, Xiaoqin, Jin, Jianhua
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.04.2015
Subjects
Adult
Asian Continental Ancestry Group - statistics & numerical data
Biomarkers - blood
Body Mass Index
Cardiovascular disease
China - epidemiology
Cholesterol
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Obesity
Obesity - epidemiology
Obesity - metabolism
Obesity, Abdominal - epidemiology
Overweight - epidemiology
Prevalence
Risk Factors
Serine Endopeptidases - blood
Womens health
China
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Summary:Objective Corin has been suggested to be associated with obesity by cell‐ and animal‐based studies. However, the association has not yet been studied in populations. Here, the aim was to explore the association in a general population of China. Methods This was a cross‐sectional study. Data on demographic information, lifestyle risk factors, and personal medical history were collected; body mass index, waist circumference, and blood pressures were measured; and serum corin, blood lipids, and blood glucose were determined in 2498 participants aged above 30 years. Results Log‐transformed corin correlated to body mass index (r = 0.197, P < 0.001) and waist circumference (r = 0.289, P < 0.001). In the risk factor‐adjusted analysis, compared with participants in the lowest quartile of serum corin, participants in the 4th quartile had significantly increased risk of prevalent overweight or obesity (OR = 2.26, 95% CI: 1.67‐3.04) and central obesity (OR = 1.74, 95% CI: 1.30‐2.34). ORs of overweight or obesity and central obesity positively and significantly increased with serum corin levels (P for trend < 0.001). Conclusions Serum soluble corin was significantly and positively associated with obesity. Our findings suggested that serum soluble corin may be a marker or risk factor for obesity.
Bibliography:HP, QZ, and JJ conceived and designed the study. HP, YL, HS, XC (Chao), and HT performed the study. HP, QZ, and XC (Cai) analyzed the data. JJ, QZ, and HS contributed reagents/materials/analysis tools. All authors were involved in writing the paper and had final approval of the submitted and published versions. This study is supported by the Suzhou Science and Technology Project (NO. SS0910 and NO. SS201333), the Innovation of Graduate Student Training Project in Jiangsu Province (NO. CXZZ13_0839), and Kunshan City and Social Development of Science and Technology Plan Project (NO. KS1360).
The authors declared no conflict of interest.
Disclosure
These authors contributed equally to this work and should be considered as co‐first authors.
Funding agencies
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21016