Association of HLA‐DRB109:01 with severe COVID‐19

• Published in: HLA Vol. 98; no. 1; pp. 37 - 42
• Main Authors: Anzurez, Alitzel, Naka, Izumi, Miki, Shoji, Nakayama‐Hosoya, Kaori, Isshiki, Mariko, Watanabe, Yusuke, Nakamura‐Hoshi, Midori, Seki, Sayuri, Matsumura, Takayuki, Takano, Tomohiro, Onodera, Taishi, Adachi, Yu, Moriyama, Saya, Terahara, Kazutaka, Tachikawa, Natsuo, Yoshimura, Yoshihiro, Sasaki, Hiroaki, Horiuchi, Hiroshi, Miyata, Nobuyuki, Miyazaki, Kazuhito, Koga, Michiko, Ikeuchi, Kazuhiko, Nagai, Hiroyuki, Saito, Makoto, Adachi, Eisuke, Yotsuyanagi, Hiroshi, Kutsuna, Satoshi, Kawashima, Akira, Miyazato, Yusuke, Kinoshita, Noriko, Kouno, Chiyoko, Tanaka, Kensuke, Takahashi, Yoshimasa, Suzuki, Tadaki, Matano, Tetsuro, Ohashi, Jun, Kawana‐Tachikawa, Ai
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2021
• Subjects: Alleles; association; Brief Communication; coronavirus disease 2019; COVID-19 - diagnosis; COVID-19 - genetics; Gene Frequency; Genetic Predisposition to Disease; Genotype; HLA-DRB1 Chains - genetics; human leukocyte antigen; Humans; Japan; risk factor; severe acute respiratory syndrome coronavirus 2; association; human leukocyte antigen; severe acute respiratory syndrome coronavirus 2; risk factor; Japan; coronavirus disease 2019
• ISSN: 2059-2302; 2059-2310
• DOI: 10.1111/tan.14256

HLA‐A, ‐C, ‐B, and ‐DRB1 genotypes were analyzed in 178 Japanese COVID‐19 patients to investigate the association of HLA with severe COVID‐19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA‐DRB1*09:01 and severe COVID‐19 (odds ratio [OR], 3.62; 95% CI, 1.57–8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID‐19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID‐19.