A meta‐analysis of the effect of endoscopic submucosal dissection compared with gastrectomy on the wound infection in early stomach cancer subjects

• Published in: International wound journal Vol. 20; no. 6; pp. 2087 - 2094
• Main Authors: Sun, Cheng, Liu, Weilin, Jiang, Jianye, Zhang, Hongyan, Wang, Pan, Sun, Jing, Sun, Aimin
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2023; John Wiley & Sons, Inc
• Subjects: Bias; Dissection; early stomach cancer; Endoscopic Mucosal Resection; endoscopic submucosal dissection; Endoscopy; gastrectomy; Gastrectomy - adverse effects; Gastrectomy - methods; Gastric cancer; Gastric Mucosa - surgery; Gastrointestinal surgery; Humans; Infections; Information sources; Lymphatic system; Meta-analysis; Original; Retrospective Studies; Statistical analysis; Stomach; Stomach Neoplasms - surgery; Treatment Outcome; wound infection; China; early stomach cancer; endoscopic submucosal dissection; wound infection; gastrectomy
• ISSN: 1742-4801; 1742-481X; 1742-481X
• DOI: 10.1111/iwj.14078

We conducted a meta‐analysis to assess the effect of endoscopic submucosal dissection compared with gastrectomy on the wound infection in early stomach cancer subjects. A systematic literature search up to November 2022 was performed and 2765 related studies were evaluated. The chosen studies comprised 7842 early stomach cancer subjects participated in the selected studies' baseline trials; 3308 of them used the endoscopic submucosal dissection, while 4534 used gastrectomy. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated to assess the wound infection in endoscopic submucosal dissection versus gastrectomy for early stomach cancer by the dichotomous methods with a random or fixed effect model. The use of endoscopic submucosal dissection resulted in significantly lower wound infection (OR, 0.45; 95% CI, 0.34–0.60, P < .001) with no heterogeneity (I2 = 8%) compared with the gastrectomy for early stomach cancer. The use of endoscopic submucosal dissection resulted in significantly lower wound infection compared with the gastrectomy for early stomach cancer. The small sample size of some studies in the comparison calls for care when analysing the results.