Spectrum and outcome of microbiologically documented Listeria monocytogenes infections in cancer patients

At the M.D. Anderson Cancer Center (Houston), Listeria monocytogenes was cultured from 14 patients between 1980 and 1987. The case records of 11 of these patients were reviewed. Underlying malignancies included acute leukemia (three), lymphoma (two), myeloma (one), adenocarcinoma of colon (two), car...

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Bibliographic Details
Published inCancer Vol. 64; no. 9; pp. 1968 - 1970
Main Authors Khardori, Nancy, Berkey, Peter, Hayat, Samina, Rosenbaum, Beverly, Bodey, Gerald P.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.11.1989
Wiley-Liss
Subjects
Adult
Aged
Ampicillin - therapeutic use
Bacterial diseases
Biological and medical sciences
Female
Human bacterial diseases
Humans
Immunosuppressive Agents - adverse effects
Infectious diseases
Listeriosis - complications
Listeriosis - drug therapy
Listeriosis - mortality
Male
Medical sciences
Meningitis, Listeria - complications
Middle Aged
Miscellaneous
Neoplasms - complications
Neoplasms - drug therapy
Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
Vancomycin - therapeutic use
Human
Prognosis
Listeria monocytogenes
Malignant tumor
Bacteremia
Infection
Chemotherapy
Treatment
Risk factor
Bacteriosis
Bacteria
Meningitis
Tumor
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Summary:At the M.D. Anderson Cancer Center (Houston), Listeria monocytogenes was cultured from 14 patients between 1980 and 1987. The case records of 11 of these patients were reviewed. Underlying malignancies included acute leukemia (three), lymphoma (two), myeloma (one), adenocarcinoma of colon (two), carcinoma of breast (one), carcinoma of lung (one), and Kaposi's sarcoma associated with the acquired immune deficiency syndrome (one). Listeria monocytogenes was cultured from blood (eight patients), cerebrospinal fluid (CSF) (two patients), and from both blood and CSF in one patient. All patients were receiving immunosuppressive therapy including corticosteroids in seven. An absolute neutrophil count of less than 1000/mm3 was noted in five. Bacteremia was the predominant type of infection and ten patients responded to antimicrobial therapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19891101)64:9<1968::AID-CNCR2820640934>3.0.CO;2-4