Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors

A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and their parents indicate that alleles lost in t...

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Bibliographic Details
Published inAmerican journal of human genetics Vol. 40; no. 5; pp. 413 - 420
Main Authors SCHROEDER, W. T, LIAN-YU CHAO, DAO, D. D, STRONG, L. C, SEN PATHAK, RICCARDI, V, LEWIS, W. H, SAUNDERS, G. F
Format Journal Article
LanguageEnglish
Published Chicago, IL University of Chicago Press 01.05.1987
Subjects
Alleles
Biological and medical sciences
Chromosome Deletion
Chromosomes, Human, Pair 11
DNA, Neoplasm - genetics
Female
Genetic Markers
Heterozygote
Humans
Kidney Neoplasms - genetics
Kidneys
Male
Medical sciences
Nephrology. Urinary tract diseases
Nucleic Acid Hybridization
Polymorphism, Restriction Fragment Length
Tumors of the urinary system
Wilms Tumor - genetics
Human
Origin
Mother
C11-Chromosome
Wilms tumor
Deletion
Biological marker
Renal disease
Child
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Summary:A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.
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ISSN:0002-9297
1537-6605