Nonfunctional parathyroid carcinoma

Parathyroid carcinoma is a rare entity accounting for 0.5% to 5% of parathyroid neoplasia. Most of these malignancies present as functional hormone-producing masses with elevated serum levels of parathormone and calcium. These tumors may also be nonfunctional. Clinical detection of nonfunctioning pa...

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Published inJournal of the National Medical Association Vol. 93; no. 7-8; pp. 251 - 255
Main Authors GIESSLER, Goetz A, BEECH, Derrick J
Format Journal Article
LanguageEnglish
Published Thorofare, NJ Slack 01.07.2001
Elsevier Limited
National Medical Association
Subjects
Biological and medical sciences
Carcinoma - pathology
Carcinoma - therapy
Endocrinopathies
Humans
Malignant tumors
Medical sciences
Parathyroid Neoplasms - pathology
Parathyroid Neoplasms - therapy
Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)
Prognosis
Endocrinopathy
Human
Biosynthesis
Review
Malignant tumor
Normal
Protein hormone
Parathormone
Treatment
Parathyroid hormone
Parathyroid diseases
Surgery
Parathyroid glands
Diagnosis
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Summary:Parathyroid carcinoma is a rare entity accounting for 0.5% to 5% of parathyroid neoplasia. Most of these malignancies present as functional hormone-producing masses with elevated serum levels of parathormone and calcium. These tumors may also be nonfunctional. Clinical detection of nonfunctioning parathyroid malignancies preoperatively is primarily based on symptoms of an expanding neck mass. This ominous complaint is typically accompanied with an advanced stage of the disease at initial diagnosis. Because there is a paucity of data in the literature regarding nonfunctioning parathyroid carcinoma, prognosis can not be readily assessed. In both functional and nonfunctional parathyroid carcinoma, early surgery has proven to be the only curative treatment approach whereas both chemotherapy and radiation therapy fail to produce systemic or regional benefit when used alone. Hence, parathyroid cancer should be considered in every patient evaluated for a neck mass regardless of the blood calcium and blood parathormone level.
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ISSN:0027-9684
1943-4693