Metal-free oxidative trifluoromethylation of indoles with CF3SO2Na on the C2 position

An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. The desired product can be obtained in 0.7 g yield. A radi...

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Bibliographic Details
Published inRSC advances Vol. 9; no. 60; pp. 35098 - 35101
Main Authors Jiao-Jiao Xie, Wang, Zhi-Qing, Guo-Fang, Jiang
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 30.10.2019
The Royal Society of Chemistry
Subjects
Chemistry
Indoles
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Summary:An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. The desired product can be obtained in 0.7 g yield. A radical intermediate may be involved in this transformation.
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ISSN:2046-2069
DOI:10.1039/c9ra07785e