Reconstruction of the orbital floor using supercritical CO2 decellularized porcine bone graft

Orbital floor fractures subsequently lead to consequences such as diplopia and enophthalmos. The graft materials used in orbital floor fractures varied from autografts to alloplastic grafts, which possess certain limitations. In the present study, a novel porcine bone matrix decellularized by superc...

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Published inInternational journal of medical sciences Vol. 18; no. 16; pp. 3684 - 3691
Main Authors Chao-Hsin Huang, Dar-Jen Hsieh, Yi-Chia, Wu, Ko‐Chung Yen, Srinivasan, Periasamy, Hsiao-Chen, Lee, Chen, Ying-Che, Su-Shin, Lee
Format Journal Article
LanguageEnglish
Published Wyoming Ivyspring International Publisher Pty Ltd 01.01.2021
Ivyspring International Publisher
Subjects
Bones
Carbon dioxide
Clinical outcomes
Collagen
Diplopia
Fractures
Infections
Injuries
Medical personnel
Medical records
Patients
Polyethylene
Research Paper
Skin & tissue grafts
Surgeons
Titanium
Transplants & implants
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Summary:Orbital floor fractures subsequently lead to consequences such as diplopia and enophthalmos. The graft materials used in orbital floor fractures varied from autografts to alloplastic grafts, which possess certain limitations. In the present study, a novel porcine bone matrix decellularized by supercritical CO2 (scCO2), ABCcolla® Collagen Bone Graft, was used for the reconstruction of the orbital framework. The study was approved by the institutional review board (IRB) of Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH). Ten cases underwent orbital floor reconstruction in KMUH in 2019. The orbital defects were fixed by the implantation of the ABCcolla® Collagen Bone Graft. Nine out of ten cases used 1 piece of customized ABCcolla® Collagen Bone Graft in each defect. The other case used 2 pieces of customized ABCcolla® Collagen Bone Graft in one defect area due to the curved outline of the defect. In the outpatient clinic, all 10 cases showed improvement of enophthalmos on CT (computerized tomography) at week 8 follow-up. No replacement of implants was needed during follow-ups. To conclude, ABCcolla® Collagen Bone Graft proved to be safe and effective in the reconstruction of the orbital floor with high accessibility, high stability, good biocompatibility, low infection rate and low complication rate.
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Competing Interests: The authors have declared that no competing interest exists.
ISSN:1449-1907
DOI:10.7150/ijms.64359