Atypical presentation of Sweet syndrome with nodular erythema and oral ulcerations provoked by Ad26.COV2.S SARS‐CoV‐2 vaccination and review of literature

• Published in: Dermatologic therapy Vol. 35; no. 12; pp. e15923 - n/a
• Main Authors: Bechtold, Agata, Owczarczyk‐Saczonek, Agnieszka
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.12.2022
• Subjects: acute febrile neutrophilic dermatosis; Ad26COVS1; COVID-19 - prevention & control; COVID-19 Vaccines - adverse effects; erythema nodosum; Humans; Oral Ulcer - diagnosis; Oral Ulcer - etiology; oral ulcerations; Review; SARS-CoV-2; Sweet syndrome; Sweet Syndrome - diagnosis; Sweet Syndrome - etiology; vaccination; Vaccination - adverse effects; erythema nodosum; Sweet syndrome; acute febrile neutrophilic dermatosis; oral ulcerations; vaccination
• ISSN: 1396-0296; 1529-8019; 1529-8019
• DOI: 10.1111/dth.15923

The aim of this article is to present the case of acute febrile neutrophilic dermatosis (Sweet syndrome—SS) after Ad26.COV2.S vaccination against SARS‐CoV‐2. To the best of our knowledge, this is the second case of SS provoked by this specific vaccine. What is more, the mildly symptomatic beginning of the disease, later followed by typical SS manifestation with a variety of symptoms including nodular erythema of the feet and oral ulcerations, made it very challenging to establish the diagnosis. The article focuses on the current literature on the acute febrile neutrophilic dermatosis, along with the coexistence with other neutrophilic dermatoses and anti‐SARS‐CoV‐2 vaccinations as provoking factors. It emphasizes the necessity for sharing the knowledge and experience on the subject of SS's clinical manifestations and underlying causes to facilitate prompt diagnosis and introduction of appropriate treatment.