Renal venous erythropoietin concentrations in hypertensive patients with unilateral renal disease

In 24 hypertensive patients with unilateral renal disease, the erythropoietin (Epo) concentration ratio in the renal veins was compared with the renin ratio. Seven patients showed moderately elevated peripheral Epo values. Epo and plasma renin activity were significantly positively correlated both i...

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Published inNephrology, dialysis, transplantation Vol. 7; no. 12; p. 1190
Main Authors Labeeuw, M, Prost, N F, Daoud, S, Lapra, C, Zech, P, Pozet, N
Format Journal Article
LanguageEnglish
Published England 1992
Subjects
Adolescent
Adult
Aged
Blood Pressure
Erythropoietin - blood
Female
Humans
Hypertension, Renal - blood
Hypertension, Renal - physiopathology
Hypertension, Renal - surgery
Hypertension, Renovascular - blood
Hypertension, Renovascular - physiopathology
Hypertension, Renovascular - surgery
Male
Middle Aged
Renal Veins
Renin - blood
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Summary:In 24 hypertensive patients with unilateral renal disease, the erythropoietin (Epo) concentration ratio in the renal veins was compared with the renin ratio. Seven patients showed moderately elevated peripheral Epo values. Epo and plasma renin activity were significantly positively correlated both in peripheral and renal veins. This suggests that the reduction of renal blood flow was a common, but not unique, stimulating factor of Epo and renin secretion. Epo ratio appeared insensitive since it was greater than 1.5 in only 30% of patients with a renin ratio > 2. Our results indicate that the Epo concentration ratio in renal veins cannot be proposed as a substitute for the currently used renin ratio.
ISSN:0931-0509
DOI:10.1093/ndt/7.12.1190