Analytical Expression for the NO Concentration Profile Following NONOate Decomposition in the Presence of Oxygen

We have derived an analytical expression for the time dependent NO concentration from NONOate donors in the presence of oxygen for the process of NO release from NO donors following autoxidation. This analytical solution incorporates the kinetics of the releases with the autoxidation and is used to...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 923; p. 435
Main Authors Rong, Zimei, Ye, Zhihui
Format Journal Article
LanguageEnglish
Published United States 2016
Subjects
Computer Simulation
Kinetics
Models, Chemical
Nitric Oxide - chemistry
Nitric Oxide Donors - chemistry
Oxidation-Reduction
Oxygen - chemistry
Autoxidation
Mathematical mode
Decomposition
NONOate
Nitric oxide
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Summary:We have derived an analytical expression for the time dependent NO concentration from NONOate donors in the presence of oxygen for the process of NO release from NO donors following autoxidation. This analytical solution incorporates the kinetics of the releases with the autoxidation and is used to fit the simulated NO concentration profile to the experimental data. This allows one to determine the NO release rate constant, k 1, the NO release stoichiometric coefficient, v NO, and the NO autoxidation reaction rate constant, k 2. This analytical solution also allows us to predict the real NO concentration released from NO donors under aerobic conditions, while v NO is reportedly two under aerobic conditions, it falls to lower values in the presence of oxygen.
ISSN:0065-2598
DOI:10.1007/978-3-319-38810-6_57