Woven bone formation around implants and the effect of bacterial infection

Several implant materials used in dental and orthopedic surgery were placed in rat tibial bones to study their effects on mineralization. The implants consisted of bone bonding and non-bonding materials. Changes in mineralization were defined by morphometric analysis of matrix vesicle distribution a...

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Bibliographic Details
Published inJournal of long-term effects of medical implants Vol. 9; no. 1-2; p. 47
Main Authors Sela, J, Gross, U M, Kohavi, D, Shani, J, Boyan, B D, Schwartz, Z, Sela, M N
Format Journal Article
LanguageEnglish
Published United States 1999
Subjects
Animals
Bacterial Infections - physiopathology
Calcinosis - pathology
Calcinosis - physiopathology
Disease Models, Animal
Osseointegration
Prostheses and Implants - adverse effects
Prosthesis-Related Infections - pathology
Prosthesis-Related Infections - physiopathology
Rats
Tibia - metabolism
Tibia - surgery
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Summary:Several implant materials used in dental and orthopedic surgery were placed in rat tibial bones to study their effects on mineralization. The implants consisted of bone bonding and non-bonding materials. Changes in mineralization were defined by morphometric analysis of matrix vesicle distribution at the implant interface and in normal bone healing following marrow injury. Bone-bonding materials induced an increase in matrix vesicle activity. This finding was supported by study of the biochemical changes in the same model that manifested high correlations to the morphometrical observations with regard to enhancement or delay of primary mineralization. In addition, the study of healing using nuclear methods indicated that implants alter bone healing as shown by the different uptakes of 99mTc and 32P in the different bone compartments. Decreased 32P uptake by the organic phase in the presence of bone-bonding implants suggested that cleavage of 99mTc-MD32P into its technetium and methylene diphosphonate moieties was inhibited by administration of implants. Further studies on the effect of bacterial infection on the peri-implant tissues revealed a decrease in woven bone formation due to infection.
ISSN:1050-6934