Mass spectrometry for the study of autism and neurodevelopmental disorders

Mass spectrometry (MS) has been increasingly used to study central nervous system disorders, including autism spectrum disorders (ASDs). The first studies of ASD using MS focused on the identification of external toxins, but current research is more directed at understanding endogenous protein chang...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 806; p. 525
Main Authors Ngounou Wetie, Armand G, Dekroon, Robert M, Mocanu, Mihaela, Ryan, Jeanne P, Darie, Costel C, Woods, Alisa G
Format Journal Article
LanguageEnglish
Published United States 01.01.2014
Subjects
Animals
Autistic Disorder - metabolism
Fragile X Syndrome - metabolism
Humans
Mass Spectrometry - methods
Proteomics - methods
Smith-Lemli-Opitz Syndrome - metabolism
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Summary:Mass spectrometry (MS) has been increasingly used to study central nervous system disorders, including autism spectrum disorders (ASDs). The first studies of ASD using MS focused on the identification of external toxins, but current research is more directed at understanding endogenous protein changes that occur in ASD (ASD proteomics). This chapter focuses on how MS has been used to study ASDs, with particular focus on proteomic analysis. Other neurodevelopmental disorders have been investigated using this technique, including genetic syndromes associated with autism such as fragile X syndrome and Smith-Lemli-Opitz syndrome.
ISSN:0065-2598
DOI:10.1007/978-3-319-06068-2_26