Autophagy and Ubiquitin-Proteasome System

Millions of protein molecules are synthesized per minute in each cell, and simultaneously, millions of protein molecules are degraded. Mutated and misfolded newly synthesized proteins are rapidly degraded to prevent the toxicity caused by the accumulation of these protein fragments. There are two ma...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 1206; p. 527
Main Authors Wang, Yan, Le, Wei-Dong
Format Journal Article
LanguageEnglish
Published United States 01.01.2019
Subjects
Autophagy
Disease Progression
Humans
Lysosomes
Proteasome Endopeptidase Complex - metabolism
Proteolysis
Ubiquitin - metabolism
Ubiquitin
Autophagy
Lysosome
Proteasome
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Summary:Millions of protein molecules are synthesized per minute in each cell, and simultaneously, millions of protein molecules are degraded. Mutated and misfolded newly synthesized proteins are rapidly degraded to prevent the toxicity caused by the accumulation of these protein fragments. There are two main mechanisms of intracellular protein degradation: the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP). There is a certain relationship between these two mechanisms, and there are some molecules that initiate compensatory effects to prevent disease progression.
ISSN:0065-2598
DOI:10.1007/978-981-15-0602-4_25