Carcinoid tumor of the pancreas. Ultrastructural observations of a lymph node metastasis and comparison with bronchial carcinoid

The clinical, pathologic, and ultrastructural findings from the case of a 64‐year‐old woman with a malignant endocrine tumor of the pancreas are presented. Clinically, the carcinoid syndrome was absent; however, elevated levels of blood serotonin and urine 5‐HIAA were recorded. Serum insulin, gastri...

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Bibliographic Details
Published inCancer Vol. 33; no. 5; pp. 1349 - 1354
Main Authors Patchefsky, Arthur S., Gordon, Gloria, Harrer, William V., Hoch, Willis S.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.05.1974
Subjects
5-Hydroxytryptophan - urine
Adrenocorticotropic Hormone - blood
Aldosterone - blood
Carcinoid Tumor - blood
Carcinoid Tumor - pathology
Carcinoid Tumor - urine
Carcinoma, Adenoid Cystic - pathology
Chromaffin System - pathology
Cortisone - blood
Female
Gastrins - blood
Humans
Hydroxyindoleacetic Acid - urine
Inclusion Bodies
Insulin - blood
Lymphatic Metastasis - pathology
Microscopy, Electron
Middle Aged
Pancreatic Neoplasms - blood
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - urine
Serotonin - blood
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Summary:The clinical, pathologic, and ultrastructural findings from the case of a 64‐year‐old woman with a malignant endocrine tumor of the pancreas are presented. Clinically, the carcinoid syndrome was absent; however, elevated levels of blood serotonin and urine 5‐HIAA were recorded. Serum insulin, gastrin, ACTH, cortisone, and aldosterone were normal. Histologically, the tumor was consistent with a carcinoid tumor. Argentaffin stains were strongly positive. Ultrastructurally, a supraclavicular lymph node metastasis contained pleomorphic secretory granules morphologically identical to those of enterochromaffin cells and carcinoid tumors of the gastrointestinal tract. Ultrastructural comparison with a pulmonary carcinoid tumor showed both to have identical pleomorphic secretory granules.
Bibliography:Associate Professor of Pathology.
Electron Microscopy Technician.
Assistant Professor of Pathology.
Assistant Professor of Pathology; Director of Laboratory, Our Lady of Lourdes Hospital, Camden, N. J.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197405)33:5<1349::AID-CNCR2820330520>3.0.CO;2-0