Increase in sister chromatid exchange rates in association with occupational exposure to N,N-dimethylformamide

The effects of occupational exposure to N,N-dimethylformamide (DMF) on sister chromatid exchange (SCE) rates were studied in peripheral lymphocytes from 22 DMF-exposed women (aged 22-52 years) in comparison with 22 sex-, age-, and residence-matched controls. All subjects were nonsmokers and nondrink...

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Bibliographic Details
Published inInternational archives of occupational and environmental health Vol. 64; no. 1; p. 65
Main Authors Seiji, K, Inoue, O, Cai, S X, Kawai, T, Watanabe, T, Ikeda, M
Format Journal Article
LanguageEnglish
Published Germany 01.01.1992
Subjects
Adult
Case-Control Studies
Dimethylformamide - analysis
Dimethylformamide - pharmacology
Female
Humans
Lymphocytes - drug effects
Middle Aged
Occupational Exposure - analysis
Sister Chromatid Exchange - drug effects
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Summary:The effects of occupational exposure to N,N-dimethylformamide (DMF) on sister chromatid exchange (SCE) rates were studied in peripheral lymphocytes from 22 DMF-exposed women (aged 22-52 years) in comparison with 22 sex-, age-, and residence-matched controls. All subjects were nonsmokers and nondrinkers as confirmed by medical interview. The 22 pairs were divided by the intensity of exposure to DMF into 3 subgroups of high-exposed (8 pairs with mean DMF exposure at 5.8 ppm), middle-exposed (5 pairs with DMF at 0.7 ppm in combination with toluene at 0.9 ppm), and low-exposed (9 pairs with DMF at 0.3 ppm). The SCE rates were significantly higher in the high (P less than 0.005) and middle (P less than 0.01) exposed than in their matched pairs, and the increase was related to the intensity of DMF exposure.
ISSN:0340-0131
DOI:10.1007/BF00625953