The Development of Antisense RNA Treatments Using Engineered Protein Substrates

Current efforts to design supercharged protein assemblies have opened the door for the creation of substrates that could be used for drug delivery and as substrates for antiviral delivery mechanisms. We explore the potential for antiviral delivery with antisense RNAs that bind their phosphate backbo...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 1339; p. 47
Main Author Harney, Michael
Format Journal Article
LanguageEnglish
Published United States 01.01.2021
Subjects
Proteins
RNA, Antisense - genetics
Antisense RNA
Drug delivery
Supercharged protein
Precision medicine
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Summary:Current efforts to design supercharged protein assemblies have opened the door for the creation of substrates that could be used for drug delivery and as substrates for antiviral delivery mechanisms. We explore the potential for antiviral delivery with antisense RNAs that bind their phosphate backbone to the charge of an engineered protein oligomer, providing structural integrity to the RNA strand and adding possible steric effects to prevent reaction with unintended targets.
ISSN:0065-2598
DOI:10.1007/978-3-030-78787-5_7