Fibroblasts in the Tumor Microenvironment

The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as ma...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 1234; p. 15
Main Authors Truffi, Marta, Sorrentino, Luca, Corsi, Fabio
Format Journal Article
LanguageEnglish
Published United States 01.01.2020
Subjects
Cancer-Associated Fibroblasts - pathology
Carcinogenesis
Humans
Neoplasms - pathology
Tumor Microenvironment
Cancer-associated fibroblasts
Cancer-stroma crosstalk
Immunosuppression
Extracellular matrix remodeling
Tumor microenvironment
Cancer treatment
Targeted therapy
Tumor neoangiogenesis
Epithelial-to-mesenchymal transition
Chemoresistance
Pro-tumorigenic cytokines
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Summary:The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors. A switch from quiescent fibroblasts to cancer-associated fibroblasts triggers a large variety of pro-tumorigenic signals that support tumor progression and shape the surrounding pathological stroma, with the remodeling of tissue architecture and repression of the local immune response. The heterogeneous nature of cancer-associated fibroblasts and their multiple functions are subject of active research as they could represent promising targets for cutting-edge therapeutic approaches to cancer and the tumor microenvironment.
ISSN:0065-2598
DOI:10.1007/978-3-030-37184-5_2