Determinants of the disparate antitumor effects of (6R)5,10-dideaza-5,6,7,8- tetrahydrofolate and methotrexate toward methotrexate resistant CCRF-CEM cells, characterized by severely impaired antifolate membrane transport

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 338; p. 783
Main Authors Matherly, L H, Angeles, S M
Format Journal Article
LanguageEnglish
Published United States 01.01.1993
Subjects
Antineoplastic Agents - toxicity
Carrier Proteins - metabolism
Cell Line
Drug Resistance
Folate Receptors, GPI-Anchored
Folic Acid Antagonists - metabolism
Folic Acid Antagonists - toxicity
Humans
Kinetics
Methotrexate - metabolism
Methotrexate - toxicity
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Receptors, Cell Surface - metabolism
Tetrahydrofolates - metabolism
Tetrahydrofolates - toxicity
Tumor Cells, Cultured
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ISSN:0065-2598
DOI:10.1007/978-1-4615-2960-6_164