Production of type I interferons: plasmacytoid dendritic cells and beyond

Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types o...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 202; no. 4; pp. 461 - 465
Main Authors Asselin-Paturel, Carine, Trinchieri, Giorgio
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 15.08.2005
Subjects
Animals
Dendritic Cells - immunology
Dendritic Cells - ultrastructure
Humans
Immunity, Innate
Interferon Type I - biosynthesis
Lymphocyte Activation - immunology
Plasma Cells - immunology
Plasma Cells - ultrastructure
Viruses - immunology
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Summary:Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique molecular mechanisms underlying the remarkably rapid and efficient type I IFN production by pDCs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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CORRESPONDENCE G.T.: trinchig@niaid.nih.gov OR C.A.-P.: carine.paturel@free.fr
ISSN:0022-1007
1540-9538
1892-1007
DOI:10.1084/jem.20051395