Impact of asthmatic control status on serum cystatin C concentrations

• Published in: Clinical chemistry and laboratory medicine Vol. 50; no. 8; pp. 1367 - 1371
• Main Authors: Shigemura, Masahiko, Konno, Satoshi, Nasuhara, Yasuyuki, Shimizu, Chikara, Matsuno, Kazuhiko, Nishimura, Masaharu
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter 01.08.2012; De Gruyter
• Subjects: Adrenal Cortex Hormones - blood; Adrenal Cortex Hormones - metabolism; Adult; Aged; Anti-Asthmatic Agents - therapeutic use; asthma; Asthma - blood; Asthma - drug therapy; Asthma - physiopathology; asthma control status; Biological and medical sciences; Chronic obstructive pulmonary disease, asthma; Cystatin C - blood; Cystatin C - metabolism; Female; General aspects; Humans; Investigative techniques, diagnostic techniques (general aspects); Kidney Function Tests; Male; Medical sciences; Middle Aged; Pneumology; serum cystatin C; Young Adult; Lung disease; Respiratory disease; s: asthma; Concentration; Asthma; Medicine; serum cystatin C; Treatment; Surveillance; Clinical biology; Cystatin C; Bronchus disease; Serum; Obstructive pulmonary disease; asthma control status
• ISSN: 1434-6621; 1437-4331; 1437-4331
• DOI: 10.1515/cclm-2011-0847

To determine whether cystatin C accurately reflects renal function in asthma, we investigated serum cystatin C concentrations in a large number of asthmatic patients by adjusting for several confounding factors that might affect serum cystatin C concentrations. A total of 126 asthmatic patients and 126 healthy volunteers, matched for age and gender, were studied. Serum cystatin C concentrations in symptomatic subjects with asthma were significantly higher than in healthy controls (p<0.001) and asymptomatic subjects with asthma (p=0.007), whereas no significant difference was observed between healthy controls and asymptomatic subjects. In asthmatic subjects, serum cystatin C concentrations were not influenced by inhaled corticosteroid (ICS). However, serum cystatin C concentrations were significantly higher in subjects who were regularly treated by oral corticosteroid (OCS) (p=0.001). Serum cystatin C concentrations are elevated in asthmatic patients; particularly while symptomatic and/or taking OCS but not ICS. Serum cystatin C concentrations may not accurately reflect renal function in those patients.