Insulin like growth factor 1 receptor signal transduction to the nucleus

The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided wit...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 343; p. 159
Main Authors Rosenzweig, S A, Oemar, B S, Law, N M, Shankavaram, U T, Miller, B S
Format Journal Article
LanguageEnglish
Published United States 01.01.1993
Subjects
Animals
Cell Nucleus - metabolism
Gene Expression Regulation
Glomerular Mesangium - metabolism
Humans
Phosphorylation
Proto-Oncogene Proteins c-jun - metabolism
Receptor, IGF Type 1 - biosynthesis
Receptor, IGF Type 1 - physiology
Receptor, Insulin - biosynthesis
Signal Transduction
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Summary:The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms triggered by IGF-1 action.
ISSN:0065-2598
DOI:10.1007/978-1-4615-2988-0_16