Chemistry of trisdecacyclic pyrazine antineoplastics: the cephalostatins and ritterazines

The research on chephalostatins and ritterazines conducted by the Petit Group is examined. Cephalostatins and ritterazines display powerful cytotoxicity against cancerous tumors.

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Bibliographic Details
Published inChemical reviews Vol. 109; no. 6; pp. 2275 - 2314
Main Authors Lee, Seongmin, LaCour, Thomas G, Fuchs, Philip L
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.06.2009
Subjects
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biomimetic Materials - chemical synthesis
Biomimetic Materials - chemistry
Cancer
Chemotherapy
Oncology
Phenazines - chemical synthesis
Phenazines - chemistry
Phenazines - pharmacology
Prescription drugs
Pyrazines - chemical synthesis
Pyrazines - chemistry
Pyrazines - pharmacology
Spiro Compounds - chemical synthesis
Spiro Compounds - chemistry
Steroids - chemical synthesis
Steroids - chemistry
Structure-Activity Relationship
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Summary:The research on chephalostatins and ritterazines conducted by the Petit Group is examined. Cephalostatins and ritterazines display powerful cytotoxicity against cancerous tumors.
Bibliography:ObjectType-Article-1
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ObjectType-Feature-3
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ObjectType-Review-2
ISSN:0009-2665
1520-6890
DOI:10.1021/cr800365m