Intercellular regulation of major histocompatibility complex class I expression in neural cells

• Published in: Immunology Vol. 80; no. 3; pp. 507 - 509
• Main Authors: TONTSCH, U, ROTT, O
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.11.1993
• Subjects: Animals; Antigens; Astrocytes - immunology; Biological and medical sciences; Cell Communication - immunology; Cells, Cultured; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Histocompatibility antigens (hla, h-2 and other systems); Histocompatibility Antigens Class I - analysis; Interferon-gamma - immunology; Molecular immunology; Neurons - immunology; Rats; Rats, Inbred Lew; Recombinant Proteins; Rat; Immunomodulation; Major histocompatibility system; Rodentia; Central nervous system; Cell cell interaction; Astrocyte; Cell surface; Vertebrata; Mammalia; Mixed cropping; Neuron; Class I histocompatibility antigen
• ISSN: 0019-2805; 1365-2567

We have studied the effect of rat central nervous system (CNS) neurons on the inducibility of major histocompatibility complex (MHC) class I molecules on syngeneic astrocytes. In a co-culture system composed of embryonic rat cortical neurons and neonatal astrocytes, intact neurons decreased constitutive expression of MHC class I determinants and inhibited the induction of class I products on astrocytes. Viability of the neurons and direct contact with astrocytes was critical for this effect. Soluble factors released by neurons were inefficient. Our data indicate that the lack of MHC class I expression on astrocytes in situ might be the result of an active suppression mechanism rather than merely due to the absence of activating factors in the CNS.