Clinical and histological features of 'mechanic's hands' in a patient with antibodies to Jo-1--a case report

The clinical and histological features of 'mechanic's hands' are described in a patient with polymyositis characterized serologically by antibodies to histidyl tRNA synthetase (Jo-1). Although described in the past in association with polymyositis, these distinctive cutaneous lesions...

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Bibliographic Details
Published inClinical and experimental dermatology Vol. 19; no. 2; p. 146
Main Authors Mitra, D, Lovell, C L, Macleod, T I, Tan, R S, Maddison, P J
Format Journal Article
LanguageEnglish
Published England 01.03.1994
Subjects
Aged
Antibodies - analysis
Female
Hand Dermatoses - immunology
Hand Dermatoses - pathology
Histidine-tRNA Ligase - immunology
Humans
Keratosis - immunology
Keratosis - pathology
Polymyositis - immunology
Polymyositis - pathology
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Summary:The clinical and histological features of 'mechanic's hands' are described in a patient with polymyositis characterized serologically by antibodies to histidyl tRNA synthetase (Jo-1). Although described in the past in association with polymyositis, these distinctive cutaneous lesions have only recently been associated with the 'anti-synthetase syndrome'. It is becoming apparent that recognition of subsets within the spectrum of polymyositis/dermatomyositis characterized by certain clinical and serological features not only have prognostic significance, but also may provide insights into mechanisms of disease.
ISSN:0307-6938
DOI:10.1111/j.1365-2230.1994.tb01144.x