African-American heredity prostate cancer study: a model for genetic research

A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome Iq (HPC11. An even greater proportion of African-American families have shown linkage to HPC 1. Therefore, investigators at the National Human Genome Research Insti...

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Published inJournal of the National Medical Association Vol. 93; no. 12 Suppl; pp. 25S - 28S
Main Authors Powell, I J, Carpten, J, Dunston, G, Kittles, R, Bennett, J, Hoke, G, Pettaway, C, Weinrich, S, Vijayakumar, S, Ahaghotu, C A, Boykin, W, Mason, T, Royal, C, Baffoe-Bonnie, A, Bailey-Wilson, J, Berg, K, Trent, J, Collins, F
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 01.12.2001
National Medical Association
Subjects
Black or African American
Black People - genetics
Human Genome Project
Humans
Male
Middle Aged
Patient Selection
Prostatic Neoplasms - ethnology
Prostatic Neoplasms - genetics
United States
United States
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Summary:A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome Iq (HPC11. An even greater proportion of African-American families have shown linkage to HPC 1. Therefore, investigators at the National Human Genome Research Institute [NHGRI] in collaboration with Howard University and a predominantly African-American group of urologists established the African-American Hereditary Prostate Cancer (AAHPC) Study Network to confirm the suggested linkage of HPC in African Americans with a gene on Chromosome 1. Blood samples from recruited families were sent to Howard University for extraction of DNA. The DNA was sent to NHGRI at NIH where the genotyping and genetic sequence analysis was conducted. Genotype data are merged with pedigree information so that statistical analysis can be performed to establish potential linkage. From March 1, 1998, to June 1, 1999, a total of 40 African-American families have been recruited who met the study criteria. Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases.
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ISSN:0027-9684
1943-4693