Insecticidal Toxin Complexes from Photorhabdus luminescens

Various bacterial toxins have potent insecticidal activity. Recently, the Toxin complexes (Tc’s) of Photorhabdus and Xenorhabdus species have become an increased focus of current research. These large tripartite toxins with molecular masses >1.4 megadaltons consist of three components termed A, B...

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Bibliographic Details
Published inCurrent topics in microbiology and immunology Vol. 402; pp. 3 - 23
Main Authors Sheets, Joel, Aktories, Klaus
Format Book Chapter Journal Article
LanguageEnglish
Published Switzerland Springer International Publishing AG 2017
Springer International Publishing
SeriesCurrent Topics in Microbiology and Immunology
Subjects
Bacteriology
Brush Border Membrane Vesicle
Medical microbiology & virology
Pharmacology
Photorhabdus Luminescens
Pore State
Toxin Complex
Toxin Component
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Summary:Various bacterial toxins have potent insecticidal activity. Recently, the Toxin complexes (Tc’s) of Photorhabdus and Xenorhabdus species have become an increased focus of current research. These large tripartite toxins with molecular masses >1.4 megadaltons consist of three components termed A, B, and C (or TcA, TcB, and TcC). While TcA is involved in receptor binding and toxin translocation, TcC possesses the specific toxin enzyme activity and TcB is a linker between components TcA and TcC. Here, a structure function analysis of the toxins is described and the application of Tc toxins as potential insecticides is discussed.
ISBN:9783319527147
3319527142
ISSN:0070-217X
2196-9965
DOI:10.1007/82_2016_55