Membrane traffic and synaptic cross‐talk during host cell entry byTrypanosoma cruzi

Summary It is widely accepted that Trypanosoma cruzi can exploit the natural exocytic response of the host to cell damage, utilizing host cell lysosomes as important effectors. It is, though, increasingly clear that the parasite also exploits endocytic mechanisms which allow for incorporation of pla...

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Published inCellular microbiology Vol. 14; no. 9; pp. 1345 - 1353
Main Authors Butler, Claire E., Tyler, Kevin M.
Format Journal Article
LanguageEnglish
Published Oxford Hindawi Limited 01.09.2012
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Summary:Summary It is widely accepted that Trypanosoma cruzi can exploit the natural exocytic response of the host to cell damage, utilizing host cell lysosomes as important effectors. It is, though, increasingly clear that the parasite also exploits endocytic mechanisms which allow for incorporation of plasma membrane into the parasitophorous vacuole. Further, that these endocytic mechanisms are involved in cross‐talk with the exocytic machinery, in the recycling of vesicles and in the manipulation of the cytoskeleton. Here we review the mechanisms by which T. cruzi exploits features of the exocytic and endocytic pathways in epithelial and endothelial cells and the evidence for cross‐talk between these pathways.
ISSN:1462-5814
1462-5822
DOI:10.1111/j.1462-5822.2012.01818.x