Mitochondrial regulation of oxygen sensing

Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by whic...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 661; p. 339
Main Author Chandel, Navdeep S
Format Journal Article
LanguageEnglish
Published United States 2010
Subjects
Adenosine Triphosphate - metabolism
Animals
Electron Transport - physiology
Hypoxia - metabolism
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Mitochondria - metabolism
Oxygen - metabolism
Procollagen-Proline Dioxygenase - metabolism
Reactive Oxygen Species - metabolism
Sodium-Potassium-Exchanging ATPase - metabolism
Ubiquinone - metabolism
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Summary:Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.
ISSN:0065-2598
DOI:10.1007/978-1-60761-500-2_22