rs294775 is a cis‐regulatory SNP for human UGT2B10

Summary UGT2B10 is an important metabolism enzyme in human body and its substrates include multiple amine‐containing compounds, especially nicotine, tamoxifen and multiple antidepressants. Multiple common SNPs have been observed in its promoter region, but their role in expression regulation has nev...

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Bibliographic Details
Published inClinical and experimental pharmacology & physiology Vol. 45; no. 6; pp. 614 - 616
Main Authors Ruan, Ji, Yang, Yu‐Chen, Long, Fu‐Quan, Sun, Chang
Format Journal Article
LanguageEnglish
Published Australia Wiley Subscription Services, Inc 01.06.2018
Subjects
Antidepressants
expression regulation
Metabolism
Mutagenesis
Nicotine
Pharmacogenetics
Pharmacology
promoter
SNP
Substrates
Tamoxifen
UGT2B10
UGT2B10
promoter
SNP
expression regulation
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Summary:Summary UGT2B10 is an important metabolism enzyme in human body and its substrates include multiple amine‐containing compounds, especially nicotine, tamoxifen and multiple antidepressants. Multiple common SNPs have been observed in its promoter region, but their role in expression regulation has never been investigated. In this preliminary study, we identified a novel cis‐regulatory SNP, rs294775, for UGT2B10 by plasmid construction, mutagenesis, and luciferase assay, whose mechanism was also investigated. Our work provides a basis for further pharmacogenetics study.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
ISSN:0305-1870
1440-1681
DOI:10.1111/1440-1681.12925