Molecular biology of the novel anticancer medications: a focus on kinases inhibitors, biologics and CAR T-cell therapy

• Published in: Inflammation research Vol. 74; no. 1; p. 41
• Main Authors: Abdo, Elia-Luna, Ajib, Imad, El Mounzer, Jason, Husseini, Mohammad, Kalaoun, Gharam, Matta, Tatiana-Maria, Mosleh, Reine, Nasr, Fidel, Richani, Nour, Khalil, Alia, Shayya, Anwar, Ghanem, Hady, Faour, Wissam H.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2025; Springer Nature B.V
• Subjects: Allergology; Animals; Antineoplastic Agents - therapeutic use; Antineoplastic drugs; Biological effects; Biological Products - therapeutic use; Biomedical and Life Sciences; Biomedicine; Biopharmaceuticals; Cancer therapies; Cell growth; Cell therapy; Chemotherapy; Dermatology; Drug delivery; Enzyme inhibitors; Humans; Immune system; Immunology; Immunosuppressive agents; Immunotherapy, Adoptive; Inhibitors; Kinases; Lymphocytes; Lymphocytes T; Molecular biology; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - therapy; Neurology; Ovarian cancer; Pharmacology/Toxicology; Protein Kinase Inhibitors - therapeutic use; Receptors, Chimeric Antigen; Review; Rheumatology; Therapy; Kinase inhibitors; Anti-cancer treatment; CAR T-cell
• ISSN: 1023-3830; 1420-908X; 1420-908X
• DOI: 10.1007/s00011-025-02008-5

Introduction Cancer treatment underwent significant changes in the last few years with the introduction of novel treatments targeting the immune system. Objectives The objective of this review is to discuss novel anticancer drugs including kinase inhibitors, biologics and cellular therapy with CAR-T cells. Methods Most recent research articles were extracted from PubMed using keywords such as “kinases inhibitors”, “CAR-T cell therapy”. Results and discussion The number of kinase inhibitors is significantly increasing due to their demonstrated effectiveness in combination with biologics. CAR-T represented a major breakthrough in the field. Also, it focused on their mechanisms of action and the rational of their use either alone or in combination in relation to their modes of action.