Topography hierarchy of biocompatible polyhydroxyalkanoate film

• Published in: RSC advances Vol. 14; no. 27; pp. 1963 - 19611
• Main Authors: Ghorabe, Fares D. E, Aglikov, Aleksandr, Novikov, Alexander S, Nosonovsky, Michael, Ryltseva, Galina A, Dudaev, Alexey E, Menzianova, Natalia G, Skorb, Ekaterina V, Shishatskaya, Ekaterina I
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 12.06.2024; The Royal Society of Chemistry
• Subjects: Autocorrelation functions; Biocompatibility; Biomedical materials; Chemistry; Data analysis; Data processing; Polyhydroxyalkanoates; Surface properties; Surface roughness; Thin films; Topography
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d4ra03398a

Polyhydroxyalkanoates (PHAs) are used for various biomedical applications due to their biocompatibility. Surface properties, such as surface roughness, are crucial for PHAs performance. Traditional parameters used for the characterization of surface roughness, such as R a , are often insufficient to capture the complex and hierarchical (multiscale) topography of PHA films. We measure the topography and surface roughness of thin PHA films with atomic force microscopy and analyze the topography data using several relatively novel data processing methods, including the calculation of autocorrelation functions, topological data analysis, and the distribution of minimum and maximum values of pixels over the topography data. The results provide details of multiscale and anisotropic surface properties that are crucial to PHAs biocompatibility but often overlooked by traditional topography analysis methods. Synthesis and characterization process of the PHB granules and film.