A multiscale model of the electrohysterogram the BioModUE_PTL project

The electrohysterogram (EHG) is a promising means of monitoring pregnancy and of detecting a risk of preterm labor. To improve our understanding of the EHG as well as its relationship with the physiologic phenomena involved in uterine contractility, we plan to model these phenomena in terms of gener...

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Published inConference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.) Vol. 2013; p. 7448
Main Authors Marque, Catherine, Laforêt, Jérémy, Rabotti, Chiara, Alexandersson, Asgeir, Germain, Guy, Gondry, Jean, Karlsson, Brynjar, Leskosek, Brane, Mischi, Massimo, Muszinski, Charles, Oei, Guid, Peuscher, Jan, Rudel, Drago
Format Journal Article
LanguageEnglish
Published United States 2013
Subjects
Computer Simulation
Electromyography
Female
Humans
Models, Biological
Multivariate Analysis
Obstetric Labor, Premature - diagnosis
Pregnancy
Sensitivity and Specificity
Uterine Contraction
Uterine Monitoring - methods
Uterus - physiology
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Summary:The electrohysterogram (EHG) is a promising means of monitoring pregnancy and of detecting a risk of preterm labor. To improve our understanding of the EHG as well as its relationship with the physiologic phenomena involved in uterine contractility, we plan to model these phenomena in terms of generation and propagation of uterine electrical activity. This activity can be realistically modeled by representing the principal ionic dynamics at the cell level, the propagation of electrical activity at the tissue level and then the way it is reflected on the skin surface through the intervening tissue. We present in this paper the different steps leading to the development and validation of a biophysics based multiscale model of the EHG, going from the cell to the electrical signal measured on the abdomen.
ISSN:1557-170X
DOI:10.1109/EMBC.2013.6611280