Prenatal diagnosis of minute 5p- deletion: a cytogenetic problem in detection

An unbalanced translocation, 46,XX,der(5)t(5;11) (p15;q25)mat was ascertained by prenatal diagnosis. The mother previously had a liveborn child with cri du chat syndrome. The subtlety of the chromosome rearrangement in this case illustrates the need for the most detailed cytogenetic investigations i...

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Bibliographic Details
Published inObstetrics and gynecology (New York. 1953) Vol. 70; no. 3 Pt 2; p. 449
Main Authors Benn, P A, Hsu, L Y, Verma, R S, Alonso, M L, Reich, E, Wishnick, M
Format Journal Article
LanguageEnglish
Published United States 01.09.1987
Subjects
Adult
Chromosome Banding - methods
Chromosome Deletion
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 5
Cri-du-Chat Syndrome - diagnosis
Female
Fetal Diseases - diagnosis
Humans
Karyotyping
Pregnancy
Prenatal Diagnosis - methods
Translocation, Genetic
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Summary:An unbalanced translocation, 46,XX,der(5)t(5;11) (p15;q25)mat was ascertained by prenatal diagnosis. The mother previously had a liveborn child with cri du chat syndrome. The subtlety of the chromosome rearrangement in this case illustrates the need for the most detailed cytogenetic investigations in cri du chat cases when deletion or translocation are not immediately obvious.
ISSN:0029-7844