Postmenopausal urinary incontinence: comparison between non-estrogen-supplemented and estrogen-supplemented women

Clinical and urodynamic variables of 49 non-estrogen-supplemented and 23 estrogen-supplemented postmenopausal women with urinary incontinence were compared. We ascertained their estrogenic status via plasma estradiol and estrone levels, as well as from parabasal and superficial cell counts from both...

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Published inObstetrics and gynecology (New York. 1953) Vol. 71; no. 6 Pt 1; p. 823
Main Authors Fantl, J A, Wyman, J F, Anderson, R L, Matt, D W, Bump, R C
Format Journal Article
LanguageEnglish
Published United States 01.06.1988
Subjects
Administration, Oral
Age Factors
Aged
Analysis of Variance
Estradiol - blood
Estrogens - administration & dosage
Estrogens - blood
Estrogens - deficiency
Estrone - blood
Female
Humans
Menopause - blood
Middle Aged
Severity of Illness Index
Urinary Bladder - pathology
Urinary Bladder - physiopathology
Urinary Incontinence - blood
Urinary Incontinence - physiopathology
Urodynamics
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Summary:Clinical and urodynamic variables of 49 non-estrogen-supplemented and 23 estrogen-supplemented postmenopausal women with urinary incontinence were compared. We ascertained their estrogenic status via plasma estradiol and estrone levels, as well as from parabasal and superficial cell counts from both the urethra and vagina. The effect of estrogen supplementation, in conjunction with the effect of age and urodynamic diagnosis, was studied in relation to filling-phase urodynamic data and incontinence severity and outcome variables. Analysis of covariance was used. No direct effect of estrogen supplementation was noted on parameters of urethral function. In patients with detrusor instability, a borderline direct positive effect (P = .06) was noted in the volume needed to reach maximal cystometric capacity from the first sensation to void. For these patients, the magnitude of fluid loss was greater without estrogen supplementation. However, this difference did not reach statistical significance. Nocturia was significantly less frequent in the estrogen-supplemented groups (P = .04). Estrogen-supplemented patients had a higher incidence of positive bulbocavernosus reflex (P = .01). These observations suggest that hypoestrogenism may affect the sensory threshold of the lower urinary tract of incontinent postmenopausal women.
ISSN:0029-7844