Prognostic significance of squamous differentiation in stage I endometrial adenocarcinoma

The prognostic implication of benign and malignant squamous differentiation was examined in 267 consecutive patients with stage I endometrial carcinoma. Patients with adenosquamous carcinoma had a significantly poorer ten-year survival rate (54.7%) than patients with adenocarcinoma (70.5%) or adenoa...

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Published inObstetrics and gynecology (New York. 1953) Vol. 68; no. 2; p. 245
Main Authors Demopoulos, R I, Dubin, N, Noumoff, J, Blaustein, A, Sommers, G M
Format Journal Article
LanguageEnglish
Published United States 01.08.1986
Subjects
Actuarial Analysis
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adult
Aged
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Female
Follow-Up Studies
Humans
Middle Aged
Neoplasm Staging
Prognosis
Time Factors
Uterine Neoplasms - mortality
Uterine Neoplasms - pathology
Uterus - pathology
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Summary:The prognostic implication of benign and malignant squamous differentiation was examined in 267 consecutive patients with stage I endometrial carcinoma. Patients with adenosquamous carcinoma had a significantly poorer ten-year survival rate (54.7%) than patients with adenocarcinoma (70.5%) or adenoacanthoma (87.4%). This was related to a tendency for adenosquamous carcinoma to be associated with poorly differentiated glandular elements and to deeply invade the myometrium. The mean depth of myometrial penetration was 57% for adenosquamous carcinoma compared with 24% for adenocarcinoma and 19% for adenoacanthoma. To examine the prognostic significance of malignant squamous differentiation independently of the grade of the associated glandular component, the subgroup of patients with well-differentiated adenocarcinoma was compared. Patients with well-differentiated adenosquamous carcinoma persisted in having a worse prognosis (58.3% ten-year survival rate), compared with adenocarcinoma (84.3% ten-year survival rate), which was explained by the propensity of adenosquamous carcinoma to deeply invade the myometrium.
ISSN:0029-7844