Plakortides, novel cyclic peroxides from the sponge Plakortis halichondrioides: Activators of cardiac SR-CA(2+)-pumping ATPase

As part of a search for novel activators of Ca2+ pumping activity of cardiac SR-(sarcoplasmic reticulum), the EtOAc extract of the Jamaican sponge Plakortis halichondrioides was shown to be active. Bioassay-guided fractionation of the extract followed by preparative TLC and HPLC yielded several know...

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Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 59; no. 3; pp. 219 - 223
Main Authors Patil, AD, Freyer, AJ, Carte, B, Johnson, RK, Lahouratate, P
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 01.03.1996
Subjects
Animals
Calcium-Transporting ATPases - metabolism
Chemistry, Medicinal
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Dioxanes - chemistry
Dioxanes - isolation & purification
Dioxanes - pharmacology
Dogs
Enzyme Activation - drug effects
Heart - drug effects
In Vitro Techniques
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Mass Spectrometry
Myocardium - enzymology
Pharmacology & Pharmacy
Plant Sciences
Porifera - metabolism
Sarcoplasmic Reticulum - enzymology
Science & Technology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
SARCOPLASMIC-RETICULUM
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Summary:As part of a search for novel activators of Ca2+ pumping activity of cardiac SR-(sarcoplasmic reticulum), the EtOAc extract of the Jamaican sponge Plakortis halichondrioides was shown to be active. Bioassay-guided fractionation of the extract followed by preparative TLC and HPLC yielded several known and novel compounds. Three of the novel cyclic peroxides, plakortides F, G, and H (3, 4, and 5) are the subject of this report. Their structures including relative stereochemistry were established by interpretation of spectral data. Micromolar concentrations of plakortides F-H (3-5) were found to significantly enhance Ca2+ uptake by SR.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/np960087v